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Vaccine Comparison

Attenuvax ProQuad
Vaccine Information Vaccine Information
  • Product Name: Measles Virus Vaccine Live
  • Tradename: Attenuvax
  • Manufacturer: Merck & Co., Inc, USA License #0002
  • Vaccine Ontology ID: VO_0000007
  • Type: Live, attenuated vaccine
  • Status: Licensed
  • Location Licensed: USA (License #0002)
  • Host Species for Licensed Use: Human
  • Antigen: A more attenuated line of measles virus derived from Enders' attenuated Edmonston strain
  • Preparation: ATTENUVAX is a sterile lyophilized preparation of a more attenuated line of measles virus derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture (FDA: Attenuvax).
  • Immunization Route: Intradermal injection (i.d.)
  • Storage: The vaccine must be maintained at a temperature of 10°C (50°F) or colder.
  • Approved Age for Licensed Use: 12 months and older
  • Contraindication: Hypersensitivity to any component of the vaccine, including gelatin, ATTENUVAX should not be administered to persons with a history of anaphylactic, anaphylactoid or other immediate reactions (e.g., hives, swelling of the mouth and throat, difficulty breathing, hypotension and shock) subsequent to egg ingestion.
  • Description: ATTENUVAX is a live virus vaccine for vaccination against measles (rubeola).
  • Product Name: Measles, Mumps, Rubella and Varicella Virus Vaccine Live
  • Tradename: ProQuad
  • Manufacturer: Merck & Co, Inc.
  • Vaccine Ontology ID: VO_0000091
  • CDC CVX code: 94
  • Type: Live, attenuated vaccine
  • Status: Licensed
  • Location Licensed: USA (License #0002)
  • Host Species for Licensed Use: Human
  • Preparation: propagated in chick embryo cell culture.
  • Immunization Route: Intramuscular injection (i.m.)
  • Storage: maintained at a temperature of 2° to 8°C (36° to 46°F) or colder.
  • Approved Age for Licensed Use: 12 months to 12 years old
  • Contraindication: Vaccine should not be administered to anyone with a known history of anaphylactic reactions to neomycin, or to anyone with a history of hypersensitivity to gelatin or any other component of the vaccine (FDA: ProQuad).
  • Description: ProQuad is a sterile lyophilized preparation of (1) the components of M-M-R*II (Measles, Mumps and Rubella Virus Vaccine Live): Measles Virus Vaccine Live, a more attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture; Mumps Virus Vaccine Live, the Jeryl Lynn™ (B level) strain of mumps virus propagated in chick embryo cell culture; Rubella Virus Vaccine Live, the Wistar RA 27/3 strain of live attenuated rubella virus propagated in WI-38 human diploid lung fibroblasts; and (2) Varicella Virus Vaccine Live (Oka/Merck) refrigerator-stable formulation, the Oka/Merck strain of varicella-zoster virus propagated in MRC-5 cells (FDA: ProQuad).
Host Response Host Response

Human Response

  • Immune Response: A single injection of the vaccine has been shown to induce measles hemagglutination-inhibition (HI) antibodies in 97% or more of susceptible persons (FDA: Attenuvax).
  • Side Effects: Side effects of vaccination include: fever, headache. dizziness, redness, soreness and swelling at the injection site.

Human Response

  • Immune Response: According to clinical trials, there were high levels of antibodies in 98.9% of those vaccinated after a single dose of Proquad (FDA: ProQuad).
  • Side Effects: Side effects of vaccination include: injection site reactions, fever, irritability and diarrhea.
References References
FDA: Attenuvax: FDA: Attenuvax information [http://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm203032.htm]
FDA: ProQuad: FDA: ProQuad Vaccine [http://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm094051.htm]