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Vaccine Comparison

Chinese S. japonicum DNA vaccine SjC23 Chinese S. japonicum DNA vaccine SjC23-Hsp70 Chinese S. japonicum DNA vaccine SjCTPI Chinese S. japonicum DNA vaccine SjCTPI-Hsp70
Vaccine Information Vaccine Information Vaccine Information Vaccine Information
  • Vaccine Ontology ID: VO_0004512
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Water buffalo
  • Sj23 gene engineering:
    • Type: DNA vaccine construction
    • Description: pVAX1 expressed SjC23 (Da'dara et al., 2008).
    • Detailed Gene Information: Click Here.
  • Vector: pVAX1 (Da'dara et al., 2008)
  • Immunization Route: Intramuscular injection (i.m.)
  • Vaccine Ontology ID: VO_0004511
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Water buffalo
  • Sj23 gene engineering:
    • Type: DNA vaccine construction
    • Description: pVAX1 expressed SjC23 and bovine heat shock protein 70 (Da'dara et al., 2008).
    • Detailed Gene Information: Click Here.
  • Vector: pVAX1 (Da'dara et al., 2008)
  • Immunization Route: Intramuscular injection (i.m.)
  • Vaccine Ontology ID: VO_0004458
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Water buffalo
  • TPI gene engineering:
    • Type: DNA vaccine construction
    • Description: This DNA vaccine expressed triose-phosphate isomerase (SjCTPI) (Da'dara et al., 2008).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
  • Vaccine Ontology ID: VO_0004459
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Water buffalo
  • TPI gene engineering:
    • Type: DNA vaccine construction
    • Description: This DNA vaccine expressed triose-phosphate isomerase (SjCTPI) fused to bovine heat shock protein 70 (Da'dara et al., 2008).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
Host Response Host Response Host Response Host Response

Water buffalo Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: This vaccine reduced worm burdens by 45.5% and fecal miracidial hatching by 47.4% after challenge (Da'dara et al., 2008).

Water buffalo Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Worm burdens were reduced by 50.9% and fecal miracidial hatching by 52.0% after challenge (Da'dara et al., 2008).

Water buffalo Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Worm burdens were reduced by 41.5% and fecal miracidial hatching were reduced by 33.2% (Da'dara et al., 2008).

Water buffalo Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: This vaccine produced a 51.2% reduction in worm burden, 61.5% liver egg reduction, 52.1% fecal egg reduction and 52.1% reduction in fecal miracidia (Da'dara et al., 2008).
References References References References
Da'dara et al., 2008: Da'dara AA, Li YS, Xiong T, Zhou J, Williams GM, McManus DP, Feng Z, Yu XL, Gray DJ, Harn DA. DNA-based vaccines protect against zoonotic schistosomiasis in water buffalo. Vaccine. 2008; 26(29-30); 3617-3625. [PubMed: 18524429].
Da'dara et al., 2008: Da'dara AA, Li YS, Xiong T, Zhou J, Williams GM, McManus DP, Feng Z, Yu XL, Gray DJ, Harn DA. DNA-based vaccines protect against zoonotic schistosomiasis in water buffalo. Vaccine. 2008; 26(29-30); 3617-3625. [PubMed: 18524429].
Da'dara et al., 2008: Da'dara AA, Li YS, Xiong T, Zhou J, Williams GM, McManus DP, Feng Z, Yu XL, Gray DJ, Harn DA. DNA-based vaccines protect against zoonotic schistosomiasis in water buffalo. Vaccine. 2008; 26(29-30); 3617-3625. [PubMed: 18524429].
Da'dara et al., 2008: Da'dara AA, Li YS, Xiong T, Zhou J, Williams GM, McManus DP, Feng Z, Yu XL, Gray DJ, Harn DA. DNA-based vaccines protect against zoonotic schistosomiasis in water buffalo. Vaccine. 2008; 26(29-30); 3617-3625. [PubMed: 18524429].