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Vaccine Comparison

C. tetani DNA vaccine pcDNA3tetC encoding fragment C Tetanus Toxoid with Calcium Phosphate Tetanus Toxoid with Stearyl Tyrosine
Vaccine Information Vaccine Information Vaccine Information
  • Vaccine Ontology ID: VO_0004414
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • TTC gene engineering:
    • Type: Recombinant protein preparation
    • Description: Vector pcDNA3 expressed fragment C (Anderson et al., 1997).
    • Detailed Gene Information: Click Here.
  • Vector: pcDNA3 (Anderson et al., 1997)
  • Immunization Route: Intramuscular injection (i.m.)
  • Vaccine Ontology ID: VO_0004230
  • Type: Toxoid vaccine
  • Status: Research
  • Adjuvant: calcium phosphate vaccine adjuvant
  • Preservative: Thimerosal (Gupta and Siber, 1994).
  • Immunization Route: subcutaneous injection
  • Vaccine Ontology ID: VO_0004231
  • Type: Toxoid vaccine
  • Status: Research
  • Adjuvant: stearyl tyrosine
  • Preservative: Thimerosal
  • Immunization Route: subcutaneous injection
Host Response Host Response Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Immune Response: Anti-Fragment C serum immunoglobulin and proliferative responses in splenocytes were observed following two immunizations with pcDNA3/tetC (Anderson et al., 1997).
  • Efficacy: Immunization of mice with Fragment C protein, the non-toxic C-terminal domain of tetanus toxin, protects mice against lethal challenge with tetanus toxin. Seven out of ten immunized mice were protected (Anderson et al., 1997).

Mouse Response

  • Host Strain: BALB/c
  • Vaccination Protocol: MIce were injected with TT preparation subcutaneously and boosted 30 days later (Gupta and Siber, 1994)
  • Immune Response: Mice immunized with CP-TT had IgG levels than mice immunized with TT adsorbed to aluminum phosphate (Gupta and Siber, 1994).

Mouse Response

  • Host Strain: BALB/c
  • Vaccination Protocol: Mice were injected with TT preparation subcutaneously and boosted 30 days later (Gupta and Siber, 1994).
  • Immune Response: Mice immunized with stearyl tyrosine TT had lower IgG responses than in mice immunized with TT adsorbed to aluminum phosphate (Gupta and Siber, 1994).
References References References
Anderson et al., 1997: Anderson R, Gao XM, Papakonstantinopoulou A, Fairweather N, Roberts M, Dougan G. Immunization of mice with DNA encoding fragment C of tetanus toxin. Vaccine. 1997; 15(8); 827-829. [PubMed: 9234525].
Gupta and Siber, 1994: Gupta RK, Siber GR. Comparison of adjuvant activities of aluminium phosphate, calcium phosphate and stearyl tyrosine for tetanus toxoid. Biologicals : journal of the International Association of Biological Standardization. 1994; 22(1); 53-63. [PubMed: 8068314].
Gupta and Siber, 1994: Gupta RK, Siber GR. Comparison of adjuvant activities of aluminium phosphate, calcium phosphate and stearyl tyrosine for tetanus toxoid. Biologicals : journal of the International Association of Biological Standardization. 1994; 22(1); 53-63. [PubMed: 8068314].