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Vaccine Detail

Coxsackievirus DNA vaccine pCMV/VPl encoding VP1
Vaccine Information
  • Vaccine Ontology ID: VO_0004361
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Macaque
  • VP1 gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pIRES expressed major structural protein (capsid protein VP1) VP1 of coxsackievirus B3 (CVB3) (Henke et al., 2004).
    • Detailed Gene Information: Click Here.
  • Vector: pIRES (Henke et al., 2004)
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: DNA immunizations with the major structural protein VP1 of coxsackievirus B3 (CVB3) have been previously found to protect mice from a lethal challenge with CVB3. Co-expression of the immune-stimulatory interleukin-2 (IL-2) can increase the efficacy of the inoculated DNA vaccine depending on the route of administration and the mouse strain used. After i.m. administration, IL-2 co-expression increased the protection rate by 18.3% whereby the g.g. inoculation was much less effective in BALB/c mice. In contrast, after g.g. inoculation IL-2 co-expression increased the protection rate by 36.7% whereby the i.m. was much less effective in C57BL/6 mice (Henke et al., 2004).
References
Henke et al., 2004: Henke A, Chiang CS, Zell R, Stelzner A. Co-expression of interleukin-2 to increase the efficacy of DNA vaccine-mediated protection in coxsackievirus B3-infected mice. Antiviral research. 2004; 64(2); 131-136. [PubMed: 15498609].