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Vaccine Detail

EAU DNA vaccine IRBP-DNA encoding IRBP
Vaccine Information
  • Vaccine Ontology ID: VO_0004402
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • IRBP from humans gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pcDNA3.1 expressed the uveitogenic retinal Ag interphotoreceptor retinoid-binding protein (IRBP) (Silver et al., 2007).
    • Detailed Gene Information: Click Here.
  • Vector: pcDNA3.1 (Silver et al., 2007)
  • Immunization Route: Intravenous injection (i.v.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Immune Response: IRBP-specific CD4+CD25high T cells could be cultured from vaccinated mice and transferred protection to unvaccinated, EAU-challenged recipients. Expression of IRBP in the periphery by DNA vaccination results in tolerance that acts at least in part through induction of IRBP-specific, FoxP3+CD4+CD25+ regulatory T cells (Silver et al., 2007).
  • Efficacy: Vaccinated mice were highly protected from EAU induced by immunization with IRBP for at least 10 weeks after vaccination (Silver et al., 2007).
References
Silver et al., 2007: Silver PB, Agarwal RK, Su SB, Suffia I, Grajewski RS, Luger D, Chan CC, Mahdi RM, Nickerson JM, Caspi RR. Hydrodynamic vaccination with DNA encoding an immunologically privileged retinal antigen protects from autoimmunity through induction of regulatory T cells. Journal of immunology (Baltimore, Md. : 1950). 2007; 179(8); 5146-5158. [PubMed: 17911600].