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Vaccine Comparison

Adjuvant arthritis DNA vaccine CII encoding type II collagen Pristane-induced arthritis DNA vaccine DNA-hsp65 encoding Mycobacterium leprae 65-kDa heat shock protein
Vaccine Information Vaccine Information
  • Vaccine Ontology ID: VO_0004409
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • Collagen type II gene engineering:
    • Type: DNA vaccine construction
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
  • Vaccine Ontology ID: VO_0004408
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • hsp65 gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pcDNA3 expressed hsp65 from M. leprae (Santos-Junior et al., 2005).
    • Detailed Gene Information: Click Here.
  • Vector: pcDNA3 (Santos-Junior et al., 2005)
  • Immunization Route: Intramuscular injection (i.m.)
Host Response Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Immune Response: In vitro analysis of anti-CII T cells demonstrated reduced production of the pro-inflammatory cytokines IFN-γ and TNF-α in CII vaccinated mice. Further, CII DNA vaccines reduced epitope spreading of auto-reactive B cell responses in CIA (Ho et al., 2006).
  • Efficacy: DNA encoding CII reduced the disease severity and disease incidence of collagen-induced arthritis to 50% as compared to the PBS-treated control group in which the disease was more severe and the disease incidence was 89% (Ho et al., 2006).
  • Host Ifng (Interferon gamma) response
    • Description: CII-stimulated lymphocytes isolated from CIA mice treated with a DNA vaccine encoding CII produced significantly less IFN-g and TNF-a compared to PBS and DNA vector-IL-4 treated mice (Ho et al., 2006).
    • Detailed Gene Information: Click Here.
  • Host TNF-alpha response
    • Description: CII-stimulated lymphocytes isolated from CIA mice treated with a DNA vaccine encoding CII produced significantly less IFN-g and TNF-a compared to PBS and DNA vector-IL-4 treated mice (Ho et al., 2006).
    • Detailed Gene Information: Click Here.

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Immune Response: Cellular and humoral immune responses to the protein are elicited, and long-lived memory lymphocytes are induced (Santos-Junior et al., 2005).
  • Efficacy: DNA-hsp65 vaccination was protective against arthritis in AIRmax mice (maximal acute inflammatory reaction), as evidenced by the absence of arthritis incidence during the 150-day follow-up period. This protective effect was more pronounced after the onset of pristane-induced arthritis (Santos-Junior et al., 2005).
References References
Ho et al., 2006: Ho PP, Higgins JP, Kidd BA, Tomooka B, Digennaro C, Lee LY, de Vegvar HE, Steinman L, Robinson WH. Tolerizing DNA vaccines for autoimmune arthritis. Autoimmunity. 2006; 39(8); 675-682. [PubMed: 17178564].
Santos-Junior et al., 2005: Santos-Junior RR, Sartori A, De Franco M, Filho OG, Coelho-Castelo AA, Bonato VL, Cabrera WH, Ibañez OM, Silva CL. Immunomodulation and protection induced by DNA-hsp65 vaccination in an animal model of arthritis. Human gene therapy. 2005; 16(11); 1338-1345. [PubMed: 16259568].