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Vaccine Detail

E. rhusiopathiae DNA vaccine pcD-ACSC
Vaccine Information
  • Vaccine Ontology ID: VO_0004539
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • spaA gene engineering:
    • Type: DNA vaccine construction
    • Description: This vaccine encoded a fusion of the spaA protein and various elements, such as a secretion leader sequence from the highly expressed human gene encoding alpha1-antitrypsin (AAT), a highly soluble and stably folded domain from the rat cartilage oligomerization matrix protein (COMP), and three copies of the complement component, C3d3 (Chen et al., 2009).
    • Detailed Gene Information: Click Here.
  • Vector: pcDNA3 (Chen et al., 2009)
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Immune Response: Immunization with the DNA vaccine expressing pcDNA3-AAT-COMP-spaAN-3C3d (pcD-ACSC) had higher antibody titers than pcDNA3-spaA(N) (pcD-S) at week 4 (Chen et al., 2009).
  • Efficacy: The protective efficacy of the spaA-chimeras was demonstrated by lethal challenge with a virulent homologous strain 1249 against immunized mice (Chen et al., 2009).
References
Chen et al., 2009: Chen KX, Li YJ, Zhang FC, Cao WY, Li JW. [Enhancement of antibodies to protective domain of surface protective antigen A of Erysipelothrix rhusiopathiae by DNA immunization with plasmids expressing spaA-chimeras]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2009; 25(11); 984-986. [PubMed: 19900362].