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Vaccine Detail

M. avium DNA vaccine DNA-Av35/p2AIL12
Vaccine Information
  • Vaccine Ontology ID: VO_0004540
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • Antigen: M. avium 35,000 MW protein (Martin et al., 2003)
  • Vector: pJW4303 (Martin et al., 2003)
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Immune Response: Co-immunization with p2AIL-12 and DNA-Av35 led to a significant increase in the number of antigen-specific IFN-gamma secreting cells and total amount of IFN-gamma released, but a concomitant fall in the antibody response to the 35000 MW protein (Martin et al., 2003).
  • Efficacy: Immunization with DNA-Av35 resulted in significant protective immunity against M. avium infection with a 2-log10 reduction in the M. avium load in the spleen (P < 0.001). The addition of p2AIL12 to the DNA-Av35 vaccine significantly increased the level of protection in both the spleen (P < 0.005) and liver (P < 0.01), with a further reduction in the bacterial load of about 1-log10 (Martin et al., 2003).
References
Martin et al., 2003: Martin E, Kamath AT, Briscoe H, Britton WJ. The combination of plasmid interleukin-12 with a single DNA vaccine is more effective than Mycobacterium bovis (bacille Calmette-Guèrin) in protecting against systemic Mycobacterim avium infection. Immunology. 2003; 109(2); 308-314. [PubMed: 12757627].