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Vaccine Detail

IBV DNA vaccine pVAX-S1 with GM-CSF adjuvant
Vaccine Information
  • Vaccine Ontology ID: VO_0004582
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Chickens
  • S1 gene engineering:
    • Type: DNA vaccine construction
    • Detailed Gene Information: Click Here.
  • Vector: pVAX1 (Tan et al., 2009)
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0003057
  • Immune Response: Vaccination with pVAX-S1 plus pVAX-chGM-CSF induced a level of anti-IBV antibodies that was significantly higher than in animals receiving pVAX-S1 alone (P < 0.05) beginning on the seventh day after booster vaccination (Tan et al., 2009).
  • Efficacy: PBS and pVAX1 immunized groups had 0% protection efficacy. The protection efficacy in the group vaccinated with the pVAX-S1 plus pVAX- chGM-CSF was 86.7%, whereas for the group vaccinated with pVAX-S1 alone, it was 73.3%. These results suggest that chGM-CSF, used as a molecular adjuvant, can improve the protection efficacy of an IBV S1 protein DNA vaccine (Tan et al., 2009).
References
Tan et al., 2009: Tan B, Wang H, Shang L, Yang T. Coadministration of chicken GM-CSF with a DNA vaccine expressing infectious bronchitis virus (IBV) S1 glycoprotein enhances the specific immune response and protects against IBV infection. Archives of virology. 2009; 154(7); 1117-1124. [PubMed: 19543689].