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Vaccine Detail

SL3261 expressing T. spiralis Ag30
Vaccine Information
  • Vaccine Ontology ID: VO_0004605
  • Type: Recombinant vector vaccine
  • Status: Research
  • Antigen: The antigen expressed on S. enterica is the "210-239 amino acid epitope, (designated as Ag30) derived from the 43 kDa glycoprotein of T. spiralis muscle larvae" (Pompa-Mera et al., 2011).
  • Vector: The strain SL3261 of the bacterium Salmonella enterica serovar Typhimurium is used as a live, attenuated vaccine vector expressing Ag30 from T. spiralis, displayed on the surface of the bacterium by the autotransporter ShdA (Pompa-Mera et al., 2011).
  • Preparation: (Pompa-Mera et al., 2011)
  • Immunization Route: intranasal immunization
  • Description: This vaccine was shown to elicit protective immunity against T. spiralis challenge, in the form of the induction of antigen-specific IgG1 and IL-5 production (Pompa-Mera et al., 2011).
Host Response

Mouse Response

  • Host Strain: BALB/c mice
  • Vaccine Immune Response Type: VO_0000287
  • Immune Response: The mice were shown to have produced antigen-specific IgG1 and IL-5 antibodies in response to T. spiralis challenge.
  • Efficacy: At day 8 post-challenge, the adult burden was reduced by 61.83% in mice that had been inoculated with the recombinant vector vaccine (Pompa-Mera et al., 2011).
  • Description: The immune response and protection offered by the vaccine shows the usefulness of S. enterica for displaying nematode epitopes found in intestinal parasites (Pompa-Mera et al., 2011).
References
Pompa-Mera et al., 2011: Pompa-Mera EN, Yépez-Mulia L, Ocaña-Mondragón A, García-Zepeda EA, Ortega-Pierres G, González-Bonilla CR. Trichinella spiralis: intranasal immunization with attenuated Salmonella enterica carrying a gp43 antigen-derived 30mer epitope elicits protection in BALB/c mice. Experimental parasitology. 2011; 129(4); 393-401. [PubMed: 21907709].