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Vaccine Detail

rMVA-CCHF
Vaccine Information
  • Vaccine Ontology ID: VO_0004665
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • Preparation: Modified Vaccinia virus Ankara was used to develop a recombinant candidate vaccine expressing the CCHF virus glycoproteins (Buttigieg et al., 2014).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0003057
  • Efficacy: This vaccine protected all recipient animals from lethal disease in a challenge model adapted to represent infection via a tick bite (Buttigieg et al., 2014).
References
Buttigieg et al., 2014: Buttigieg KR, Dowall SD, Findlay-Wilson S, Miloszewska A, Rayner E, Hewson R, Carroll MW. A novel vaccine against Crimean-Congo Haemorrhagic Fever protects 100% of animals against lethal challenge in a mouse model. PloS one. 2014; 9(3); e91516. [PubMed: 24621656].