• Vaccine Ontology ID: VO_0004605
• Type: Recombinant vector vaccine
• Status: Research
• Antigen: The antigen expressed on S. enterica is the "210-239 amino acid epitope, (designated as Ag30) derived from the 43 kDa glycoprotein of T. spiralis muscle larvae" (Pompa-Mera et al., 2011).
• Vector: The strain SL3261 of the bacterium Salmonella enterica serovar Typhimurium is used as a live, attenuated vaccine vector expressing Ag30 from T. spiralis, displayed on the surface of the bacterium by the autotransporter ShdA (Pompa-Mera et al., 2011).
• Preparation: (Pompa-Mera et al., 2011)
• Immunization Route: intranasal immunization
• Description: This vaccine was shown to elicit protective immunity against T. spiralis challenge, in the form of the induction of antigen-specific IgG1 and IL-5 production (Pompa-Mera et al., 2011).

Mouse Response

• Host Strain: BALB/c mice
• Vaccine Immune Response Type: VO_0000287
• Immune Response: The mice were shown to have produced antigen-specific IgG1 and IL-5 antibodies in response to T. spiralis challenge.
• Efficacy: At day 8 post-challenge, the adult burden was reduced by 61.83% in mice that had been inoculated with the recombinant vector vaccine (Pompa-Mera et al., 2011).
• Description: The immune response and protection offered by the vaccine shows the usefulness of S. enterica for displaying nematode epitopes found in intestinal parasites (Pompa-Mera et al., 2011).