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Vaccine Detail

T. cruzi DNA vaccine encoding TSA-1 and Tc24
Vaccine Information
  • Vaccine Ontology ID: VO_0004532
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Dogs
  • Tc24 from Trypanosoma cruzi gene engineering:
    • Type: DNA vaccine construction
    • Detailed Gene Information: Click Here.
  • TSA-1 gene engineering:
    • Type: DNA vaccine construction
    • Detailed Gene Information: Click Here.
  • Vector: pcDNA3.1 (Quijano-Hernández et al., 2013)
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Dog Response

  • Efficacy: Both preventive and therapeutic vaccination significantly reduced parasitemia, cardiac inflammation and cardiac parasite burden, and tended to reduce the development of cardiac arrhythmias (Quijano-Hernández et al., 2013).
References
Quijano-Hernández et al., 2013: Quijano-Hernández IA, Castro-Barcena A, Vázquez-Chagoyán JC, Bolio-González ME, Ortega-López J, Dumonteil E. Preventive and therapeutic DNA vaccination partially protect dogs against an infectious challenge with Trypanosoma cruzi. Vaccine. 2013; 31(18); 2246-2252. [PubMed: 23499599].