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Vaccine Detail

RCN-F1-V (Yersinia pestis F1 and V)
Vaccine Information
  • Vaccine Ontology ID: VO_0004692
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • Preparation: Recombinant raccoon poxvirus (RCN) expressing plague antigens (fraction 1 [F1] and a truncated form of the V protein-V307) (Rocke et al., 2010).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Dog Response

  • Host Strain: black-tailed prairie dogs (Cynomys ludovicianus)
  • Vaccination Protocol: Voluntary consumption of baits expressing plague antigens several times over the course of several months to a group of 16 black-tailed prairie dogs. Another group of prairie dogs was injected subcutaneously (SC) (prime and boost) with 40 microg of F1-V fusion protein absorbed to alum, a vaccine-adjuvant combination demonstrated to elicit immunity to plague in mice and other mammals. Control animals received baits containing RCN without the inserted antigen or injected diluent (Rocke et al., 2010).
  • Vaccine Immune Response Type: VO_0003057
  • Challenge Protocol: Three weeks after consumption of the final vaccine-laden bait and 10 weeks after the injectable vaccine administration, animals were challenged with the CO92 wild-type isolate of Y. pestis (provided by USAMRIID), a highly virulent and well- characterized strain (Rocke et al., 2010).
  • Efficacy: The oral vaccination of prairie dogs using RCN-based plague vaccines provided significant protection against challenge at dosages that simulate simultaneous delivery of the plague bacterium by numerous flea bites.
References