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Vaccine Detail

DNA vaccine encoding ANDV glycoproteins
Vaccine Information
  • Vaccine Ontology ID: VO_0004119
  • Type: DNA vaccine
  • Antigen: Both the G1 and G2 glycoproteins are expressed (Custer et al., 2003).
  • Hanta_G2 gene engineering:
    • Type: Recombinant protein preparation
    • Description: The Hantavirus G2 glycoprotein was expressed in the DNA vaccine (Custer et al., 2003).
    • Detailed Gene Information: Click Here.
  • Vector: pWRG/HTN-M(x), a customized plasmid built from pWRG7077 (Custer et al., 2003)
  • Preparation: An expression plasmid, pWRG/AND-M, was constructed that contains the full-length M genome segment of Andes virus (ANDV), a South American hantavirus (Custer et al., 2003).
Host Response

Macaque Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Rhesus macaques vaccinated by gene gun with pWRG/AND-M developed remarkably high levels of neutralizing antibodies that not only neutralized ANDV (a South American hantavirus) but also cross-neutralized other HPS-associated hantaviruses, including Sin Nombre virus (Custer et al., 2003).
References
Custer et al., 2003: Custer DM, Thompson E, Schmaljohn CS, Ksiazek TG, Hooper JW. Active and passive vaccination against hantavirus pulmonary syndrome with Andes virus M genome segment-based DNA vaccine. Journal of virology. 2003 Sep; 77(18); 9894-905. [PubMed: 12941899 ].