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Vaccine Detail

Shigella flexneri envZ mutant vaccine
Vaccine Information
  • Product Name: SC433
  • Vaccine Ontology ID: VO_0002924
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Macaque monkey
  • envZ gene engineering:
    • Type: Gene mutation
    • Description: This envZ mutant is from Shigella flexneri (Sansonetti et al., 1991).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intragastric immunization
Host Response

Macaque Response

  • Persistence: An envZ mutant (SC433) is greatly decreased in virulence in macaque monkeys, though some mild clinical signs were still recorded (Sansonetti et al., 1991).
  • Efficacy: An envZ mutant is highly protective in macaque monkeys against a challenge of wild type S. flexneri delivered 1 month after inoculation (Sansonetti et al., 1991).
References
Sansonetti et al., 1991: Sansonetti PJ, Arondel J, Fontaine A, d'Hauteville H, Bernardini ML. OmpB (osmo-regulation) and icsA (cell-to-cell spread) mutants of Shigella flexneri: vaccine candidates and probes to study the pathogenesis of shigellosis. Vaccine. 1991; 9(6); 416-422. [PubMed: 1887672].