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Vaccine Comparison

CAdVax-Den12/Den34 Dengue virus DNA vaccine sA encoding prM and E from Dengue Virus 4 Dengue virus DNA vaccine sABC encoding prM and E Dengue virus DNA vaccine sB encoding E Dengue virus DNA vaccine sC encoding prM and E
Vaccine Information Vaccine Information Vaccine Information Vaccine Information Vaccine Information
  • Vaccine Ontology ID: VO_0004643
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • Preparation: using a complex adenovirus vector, by incorporating the genes expressing premembrane (prM) and envelope (E) proteins of dengue virus types 1 and 2 (dengue-1 and -2, respectively) (CAdVax-Den12) or dengue-3 and -4 (CAdVax-Den34) (Raviprakash et al., 2008).
  • Immunization Route: Intramuscular injection (i.m.)
  • Vaccine Ontology ID: VO_0004466
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Macaque
  • E protein gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pMV10.1 expressed prM and E genes in which the N-terminal 90% of E gene was shuffled (Raviprakash et al., 2006).
    • Detailed Gene Information: Click Here.
  • prM gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pMV10.1 expressed prM and E genes in which the N-terminal 90% of E gene was shuffled (Raviprakash et al., 2006).
    • Detailed Gene Information: Click Here.
  • Vector: pMV10.1 (Raviprakash et al., 2006)
  • Immunization Route: Intramuscular injection (i.m.)
  • Vaccine Ontology ID: VO_0004469
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Macaque
  • E protein gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pMV10.1 expressed premembrane and envelope genes of each of four serotypes of dengue viruses (Raviprakash et al., 2006).
    • Detailed Gene Information: Click Here.
  • prM gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pMV10.1 expressed premembrane and envelope genes of each of four serotypes of dengue viruses (Raviprakash et al., 2006).
    • Detailed Gene Information: Click Here.
  • 18H6 synthetic E protein gene engineering:
    • Type: DNA vaccine construction
    • Description: This combination vaccine encoded all the proteins from all 3 vaccines (Raviprakash et al., 2006).
    • Detailed Gene Information: Click Here.
  • Vector: pMV10.1 (Raviprakash et al., 2006)
  • Immunization Route: Intramuscular injection (i.m.)
  • Vaccine Ontology ID: VO_0004467
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Macaque
  • 18H6 synthetic E protein gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pMV10.1 expressed a shuffled truncated E protein (Raviprakash et al., 2006).
    • Detailed Gene Information: Click Here.
  • Vector: pMV10.1 (Raviprakash et al., 2006)
  • Immunization Route: Intramuscular injection (i.m.)
  • Vaccine Ontology ID: VO_0004468
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Macaque
  • E protein gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pMV10.1 expressed prM and E genes in which the N-terminal 90% of E gene was shuffled.a shuffled truncated E protein (Raviprakash et al., 2006).
    • Detailed Gene Information: Click Here.
  • prM gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pMV10.1 expressed prM and E genes in which the N-terminal 90% of E gene was shuffled.a shuffled truncated E protein (Raviprakash et al., 2006).
    • Detailed Gene Information: Click Here.
  • Vector: pMV10.1 (Raviprakash et al., 2006)
  • Immunization Route: Intramuscular injection (i.m.)
Host Response Host Response Host Response Host Response Host Response

Macaque Response

  • Vaccination Protocol: Rhesus macaques were vaccinated by intramuscular inoculation of a tetravalent dengue vaccine formulated by combining the two bivalent vaccine constructs (Raviprakash et al., 2008).
  • Vaccine Immune Response Type: VO_0003057
  • Challenge Protocol: The ability of the vaccine to induce rapid, as well as sustained, protective immune responses was examined with two separate live-virus challenges administered at 4 and 24 weeks after the final vaccination (Raviprakash et al., 2008).
  • Efficacy: For both of these virus challenge studies, significant protection from viremia was demonstrated for all four dengue virus serotypes in vaccinated animals. Viremia from dengue-1 and dengue-3 challenges was completely blocked, whereas viremia from dengue-2 and dengue-4 was significantly reduced, as well as delayed, compared to that of control-vaccinated animals (Raviprakash et al., 2008).

Macaque Response

  • Vaccine Immune Response Type: VO_0000286
  • Immune Response: Five of six animals vaccinated developed antibodies that neutralized all 4 dengue serotypes in vitro (Raviprakash et al., 2006).
  • Efficacy: When challenged with live dengue-1 or dengue-2 virus, partial protection against dengue-1 was observed (Raviprakash et al., 2006).

Macaque Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: When challenged with live dengue-1 or dengue-2 virus, partial protection against dengue-1 was observed. The best protection against dengue-1 viremia was demonstrated by the mixture of shuffled vaccines (sABC) out of all the vaccines tested (Raviprakash et al., 2006).

Macaque Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: When challenged with live dengue-1 or dengue-2 virus, partial protection against dengue-1 was observed (Raviprakash et al., 2006).

Macaque Response

  • Vaccine Immune Response Type: VO_0000286
  • Immune Response: Four of six animals vaccinated developed antibodies that neutralized all 4 dengue serotypes in vitro (Raviprakash et al., 2006).
  • Efficacy: When challenged with live dengue-1 or dengue-2 virus, partial protection against dengue-1 was observed (Raviprakash et al., 2006).
References References References References References
Raviprakash et al., 2008: Raviprakash K, Wang D, Ewing D, Holman DH, Block K, Woraratanadharm J, Chen L, Hayes C, Dong JY, Porter K. A tetravalent dengue vaccine based on a complex adenovirus vector provides significant protection in rhesus monkeys against all four serotypes of dengue virus. Journal of virology. 2008; 82(14); 6927-6934. [PubMed: 18480438].
Raviprakash et al., 2006: Raviprakash K, Apt D, Brinkman A, Skinner C, Yang S, Dawes G, Ewing D, Wu SJ, Bass S, Punnonen J, Porter K. A chimeric tetravalent dengue DNA vaccine elicits neutralizing antibody to all four virus serotypes in rhesus macaques. Virology. 2006; 353(1); 166-173. [PubMed: 16814355].
Raviprakash et al., 2006: Raviprakash K, Apt D, Brinkman A, Skinner C, Yang S, Dawes G, Ewing D, Wu SJ, Bass S, Punnonen J, Porter K. A chimeric tetravalent dengue DNA vaccine elicits neutralizing antibody to all four virus serotypes in rhesus macaques. Virology. 2006; 353(1); 166-173. [PubMed: 16814355].
Raviprakash et al., 2006: Raviprakash K, Apt D, Brinkman A, Skinner C, Yang S, Dawes G, Ewing D, Wu SJ, Bass S, Punnonen J, Porter K. A chimeric tetravalent dengue DNA vaccine elicits neutralizing antibody to all four virus serotypes in rhesus macaques. Virology. 2006; 353(1); 166-173. [PubMed: 16814355].
Raviprakash et al., 2006: Raviprakash K, Apt D, Brinkman A, Skinner C, Yang S, Dawes G, Ewing D, Wu SJ, Bass S, Punnonen J, Porter K. A chimeric tetravalent dengue DNA vaccine elicits neutralizing antibody to all four virus serotypes in rhesus macaques. Virology. 2006; 353(1); 166-173. [PubMed: 16814355].