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Vaccine Detail

EAE DNA vaccine pZZ/MBP68–85 encoding MBP
Vaccine Information
  • Vaccine Ontology ID: VO_0004401
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Rat
  • MBP gene engineering:
    • Type: DNA vaccine construction
    • Description: This DNA vaccine expressed an autoantigenic peptide, myelin basic protein peptide 68-85, from guinea pigs (Lobell et al., 1999).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Rat Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: The pZZ/MBP68–85-treated rats were protected from EAE. The control plasmid pZZ, which does not encode MBP68–85, failed to protect from EAE (Lobell et al., 1999)
References
Lobell et al., 1999: Lobell A, Weissert R, Eltayeb S, Svanholm C, Olsson T, Wigzell H. Presence of CpG DNA and the local cytokine milieu determine the efficacy of suppressive DNA vaccination in experimental autoimmune encephalomyelitis. Journal of immunology (Baltimore, Md. : 1950). 1999; 163(9); 4754-4762. [PubMed: 10528174].