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Vaccine Detail

HIV DNA vaccine pCMN160
Vaccine Information
  • Vaccine Ontology ID: VO_0004345
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Chimpanzee
  • Antigen: env and rev of HIV-1 strain MN and gag/pol from HIV-1 III8 (Boyer et al., 1997)
  • env gene engineering:
    • Type: DNA vaccine construction
    • Description: This DNA vaccine encoded env (Boyer et al., 1997).
    • Detailed Gene Information: Click Here.
  • rev MN isolate gene engineering:
    • Type: DNA vaccine construction
    • Description: This DNA vaccine encoded rev (Boyer et al., 1997).
    • Detailed Gene Information: Click Here.
  • gag-pol gene engineering:
    • Type: DNA vaccine construction
    • Description: This DNA vaccine encoded gag/pol from HIV-1 III8 (Boyer et al., 1997).
    • Detailed Gene Information: Click Here.
  • Vector: pCMN160 (Boyer et al., 1997)
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Chimpanzee Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Animals were challenged with a heterologous chimpanzee titered stock of HIV-1 SF2 virus. Polymerase chain reaction coupled with reverse transcription results indicated infection in the control animal, whereas those animals vaccinated with the DNA constructs were protected from the establishment of infection (Boyer et al., 1997).
References
Boyer et al., 1997: Boyer JD, Ugen KE, Wang B, Agadjanyan M, Gilbert L, Bagarazzi ML, Chattergoon M, Frost P, Javadian A, Williams WV, Refaeli Y, Ciccarelli RB, McCallus D, Coney L, Weiner DB. Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination. Nature medicine. 1997; 3(5); 526-532. [PubMed: 9142121].