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Vaccine Comparison

VHSV DNA vaccine pCMV-vhsG encoding glycoprotein G VHSV DNA vaccine pCMV-vhsN encoding nucleocapsid protein N and glycoprotein G VHSV DNA vaccine pVHS-G encoding glycoproteins
Vaccine Information Vaccine Information Vaccine Information
  • Vaccine Ontology ID: VO_0004338
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Zebra fish
  • Glycoprotein gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pcDNA3 expressed glycoprotein G gene of the virus (Heppel et al., 1997).
    • Detailed Gene Information: Click Here.
  • Vector: pcDNA3 (Heppel et al., 1997)
  • Immunization Route: Intramuscular injection (i.m.)
  • Vaccine Ontology ID: VO_0004339
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Rainbow trout
  • nucleocapsid gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pcDNA 3 expressed the gene encoding the nucleocapsid protein N (Heppel et al., 1997).
    • Detailed Gene Information: Click Here.
  • Glycoprotein gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pcDNA3 expressed glycoprotein G gene of the virus (Heppel et al., 1997).
    • Detailed Gene Information: Click Here.
  • Vector: pcDNA 3 (Heppel et al., 1997)
  • Immunization Route: Intramuscular injection (i.m.)
  • Vaccine Ontology ID: VO_0004494
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Fish
  • Glycoprotein gene engineering:
    • Type: DNA vaccine construction
    • Description: The pcDNA3.1(+) vector expressed viral glycoproteins (G proteins) (Lorenzen et al., 2002).
    • Detailed Gene Information: Click Here.
  • Vector: pcDNA3.1(+) vector (Lorenzen et al., 2002)
  • Immunization Route: Intramuscular injection (i.m.)
Host Response Host Response Host Response

Rainbow trout Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Young rainbow trout injected with the G construct, alone or together with the N construct, were strongly protected against challenge with live virus (Heppel et al., 1997).

Rainbow trout Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Young rainbow trout injected with the G construct together with the N construct were strongly protected against challenge with live virus (Heppel et al., 1997).

Rainbow trout Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Challenge experiments revealed that immunity established shortly after vaccination was cross-protective between the VHSV and IHNV whereas no increased survival was found upon challenge with bacterial pathogens. Within two months after vaccination, the cross-protection disappeared while the specific immunity to homologous virus remained high (Lorenzen et al., 2002).
References References References
Heppel et al., 1997: JOËL HEPPELL, NIELS LORENZEN, NEIL K. ARMSTRONG, TONG WU, ELLEN LORENZEN, KATJA EINER-JENSEN, JOACHIM SCHORR, HEATHER L. DAVIS. Development of DNA vaccines for fish: vector design, intramuscular injection and antigen expression using viral haemorrhagic septicaemia virus genes as model. Fish & Shellfish Immunology. 1997; 8(4); 271-286.
Heppel et al., 1997: JOËL HEPPELL, NIELS LORENZEN, NEIL K. ARMSTRONG, TONG WU, ELLEN LORENZEN, KATJA EINER-JENSEN, JOACHIM SCHORR, HEATHER L. DAVIS. Development of DNA vaccines for fish: vector design, intramuscular injection and antigen expression using viral haemorrhagic septicaemia virus genes as model. Fish & Shellfish Immunology. 1997; 8(4); 271-286.
Lorenzen et al., 2002: Lorenzen N, Lorenzen E, Einer-Jensen K, LaPatra SE. Immunity induced shortly after DNA vaccination of rainbow trout against rhabdoviruses protects against heterologous virus but not against bacterial pathogens. Developmental and comparative immunology. 2002; 26(2); 173-179. [PubMed: 11696382].