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Vaccine Comparison

E. coli-CPPs (Edwardsiella tarda) E. tarda DNA vaccine pCE18 E. tarda DNA vaccine pCE6 E. tarda DNA vaccine pCEsa1 Edwardsiella tarda aroC mutant vaccine Edwardsiella tarda aroC/esrC mutant vaccine Edwardsiella tarda aroC/slyA mutant vaccine Edwardsiella tarda esrB mutant vaccine
Vaccine Information Vaccine Information Vaccine Information Vaccine Information Vaccine Information Vaccine Information Vaccine Information Vaccine Information
  • Vaccine Ontology ID: VO_0004640
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • Preparation: GFP-TAT synthesis circuit was combined with an in vivo inducible lysis circuit PviuA-E in E. coli to form an integrated antigen delivery system (Ma et al., 2014).
  • Immunization Route: Intramuscular injection (i.m.)
  • Vaccine Ontology ID: VO_0004556
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Japanese flounder
  • Antigen: FliC-Et18 fusion protein from E. tarda TX1 (Jiao et al., 2009)
  • et18 gene engineering:
    • Type: DNA vaccine construction
    • Detailed Gene Information: Click Here.
  • fliC gene engineering:
    • Type: DNA vaccine construction
    • Detailed Gene Information: Click Here.
  • Vector: pCN3 (Jiao et al., 2009)
  • Immunization Route: Intramuscular injection (i.m.)
  • Vaccine Ontology ID: VO_0004557
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Japanese flounder
  • Antigen: FliC-Eta6 fusion protein from E. tarda TX1 (Jiao et al., 2009)
  • fliC gene engineering:
    • Type: DNA vaccine construction
    • Detailed Gene Information: Click Here.
  • eta6 gene engineering:
    • Type: DNA vaccine construction
    • Detailed Gene Information: Click Here.
  • Vector: pCN3 (Jiao et al., 2009)
  • Immunization Route: Intramuscular injection (i.m.)
  • Vaccine Ontology ID: VO_0004558
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Japanese flounder
  • Antigen: Esa1 from E. tarda TX1 (Sun et al., 2011)
  • esa1 gene engineering:
    • Type: DNA vaccine construction
    • Detailed Gene Information: Click Here.
  • Vector: pCN3 (Sun et al., 2011)
  • Immunization Route: Intramuscular injection (i.m.)
  • Vaccine Ontology ID: VO_0002830
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Zebra fish
  • aroC gene engineering:
    • Type: Gene mutation
    • Description: This aroC mutant is from Edwardsiella tarda (Xiao et al., 2011)
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Zebra fish
  • aroC gene engineering:
    • Type: Gene mutation
    • Description: This aroC/esrC mutant is from Edwardsiella tarda (Xiao et al., 2011).
    • Detailed Gene Information: Click Here.
  • esrC gene engineering:
    • Type: Gene mutation
    • Description: This aroC/esrC mutant is from Edwardsiella tarda (Xiao et al., 2011).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Zebra fish
  • slyA gene engineering:
    • Type: Gene mutation
    • Description: An aroC and slyA mutant is attenuated in zebra fish. This mutant is also protective against challenge from wild type E. tarda, resulting in a relative percent survival of 80.1% (Xiao et al., 2011).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
  • Vaccine Ontology ID: VO_0002833
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Fish
  • esrB gene engineering:
    • Type: Gene mutation
    • Description: This esrB mutant is from Edwardsiella tarda (Lan et al., 2007).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intraperitoneal injection (i.p.)
Host Response Host Response Host Response Host Response Host Response Host Response Host Response Host Response

Fish Response

  • Vaccine Immune Response Type: VO_0003057
  • Challenge Protocol: Hosts were challenged with E. tarda EIB202 (Ma et al., 2014).
  • Efficacy: This E. coli vector vaccine presented superior immune protection under the challenge with E. tarda EIB202, suggesting that the novel antigen delivery system had great potential in bacterial vector vaccine applications (Ma et al., 2014).

Fish Response

  • Vaccine Immune Response Type: VO_0003057
  • Efficacy: Following TX1 challenge, fish immunized with pCE18, pCN3 (plasmid), and PBS exhibited cumulative mortalities of 35%, 90%, and 95%, respectively. Hence, with pCN3 as a control, the protective efficacy of pCE18 was 61% in terms of RPS (Jiao et al., 2009).

Fish Response

  • Vaccine Immune Response Type: VO_0003057
  • Efficacy: Upon exposure to TX1 challenge, the cumulative mortalities of the pCE6-, pCN3-, and PBS-vaccinated fish were 25%, 90%, and 95%, respectively. Therefore, compared to vaccination with pCN3, vaccination with pCE6 produced a RPS of 72%, which is significantly higher than that produced by pEta6 (Jiao et al., 2009).

Fish Response

  • Vaccine Immune Response Type: VO_0003057
  • Efficacy: The accumulated mortalities of pCEsa1-, pCN3-, and PBS-vaccinated fish were 20%, 76%, and 80%, respectively. Hence, compared to PBS-vaccinated fish, pCEsa1-vaccinated fish were significantly (P < 0.05) protected, with a RPS of 75% (Sun et al., 2011).

Fish Response

  • Persistence: An aroC mutant is attenuated in zebra fish (Xiao et al., 2011).
  • Efficacy: An aroC mutant is protective in zebra fish against challenge from wild type E. tarda, resulting in a 68.3% relative percent survival (Xiao et al., 2011).

Fish Response

  • Persistence: This aroC/esrC mutant is attenuated in zebra fish (Xiao et al., 2011).
  • Efficacy: This aroC/esrC mutant is protective against challenge from wild type E. tarda, with a 71.3% relative percent survival (Xiao et al., 2011).

Fish Response

  • Persistence: This aroC/slyA mutant is attenuated in zebra fish (Xiao et al., 2011).
  • Efficacy: This aroC/slyA mutant is protective in zebra fish against challenge with wild type E. tarda. The percent relative survival is 80.1% (Xiao et al., 2011).

Fish Response

  • Persistence: A esrB mutant is attenuated in fish (Lan et al., 2007).
  • Efficacy: An esrB mutant induces significant protection in fish from challenge with wild type Edwardsiella tarda (Lan et al., 2007).
References References References References References References References References
Ma et al., 2014: Ma J, Xu J, Guan L, Hu T, Liu Q, Xiao J, Zhang Y. Cell-penetrating peptides mediated protein cross-membrane delivery and its use in bacterial vector vaccine. Fish & shellfish immunology. 2014; 39(1); 8-16. [PubMed: 24746937].
Jiao et al., 2009: Jiao XD, Zhang M, Hu YH, Sun L. Construction and evaluation of DNA vaccines encoding Edwardsiella tarda antigens. Vaccine. 2009; 27(38); 5195-5202. [PubMed: 19596416].
Jiao et al., 2009: Jiao XD, Zhang M, Hu YH, Sun L. Construction and evaluation of DNA vaccines encoding Edwardsiella tarda antigens. Vaccine. 2009; 27(38); 5195-5202. [PubMed: 19596416].
Sun et al., 2011: Sun Y, Liu CS, Sun L. Construction and analysis of the immune effect of an Edwardsiella tarda DNA vaccine encoding a D15-like surface antigen. Fish & shellfish immunology. 2011; 30(1); 273-279. [PubMed: 21059395].
Xiao et al., 2011: Xiao J, Chen T, Wang Q, Liu Q, Wang X, Lv Y, Wu H, Zhang Y. Search for live attenuated vaccine candidate against edwardsiellosis by mutating virulence-related genes of fish pathogen Edwardsiella tarda. Letters in applied microbiology. 2011; ; . [PubMed: 21777261].
Xiao et al., 2011: Xiao J, Chen T, Wang Q, Liu Q, Wang X, Lv Y, Wu H, Zhang Y. Search for live attenuated vaccine candidate against edwardsiellosis by mutating virulence-related genes of fish pathogen Edwardsiella tarda. Letters in applied microbiology. 2011; ; . [PubMed: 21777261].
Xiao et al., 2011: Xiao J, Chen T, Wang Q, Liu Q, Wang X, Lv Y, Wu H, Zhang Y. Search for live attenuated vaccine candidate against edwardsiellosis by mutating virulence-related genes of fish pathogen Edwardsiella tarda. Letters in applied microbiology. 2011; ; . [PubMed: 21777261].
Lan et al., 2007: Lan MZ, Peng X, Xiang MY, Xia ZY, Bo W, Jie L, Li XY, Jun ZP. Construction and characterization of a live, attenuated esrB mutant of Edwardsiella tarda and its potential as a vaccine against the haemorrhagic septicaemia in turbot, Scophthamus maximus (L.). Fish & shellfish immunology. 2007; 23(3); 521-530. [PubMed: 17478097].