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Vaccine Detail

IHNV DNA vaccine pCDNA-G encoding G
Vaccine Information
  • Vaccine Ontology ID: VO_0004420
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Rainbow trout, salmon
  • G glycoprotein gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pCDNA3.1 expressed the glycoprotein (G) (Corbeil et al., 1999).
    • Detailed Gene Information: Click Here.
  • Vector: pCDNA3.1 (Corbeil et al., 1999)
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Fish Response

  • Vaccine Immune Response Type: VO_0000286
  • Immune Response: The G protein expressed by the DNA vaccine construct did confer significant protection in fry up to 80 days post-immunization and induced protective neutralizing antibodies (Corbeil et al., 1999).
  • Efficacy: Cumulative percent mortality in fish immunized with pCDNA-G ranged from 0 to 2% whereas mortality in fish immunized with DNA vaccines that contained other proteins or were left unhandled ranged from 36 to 76%. Significant protection was elicited up to 80 days post-immunization, and the vaccine also induced protective neutralizing antibodies (Corbeil et al., 1999).
References
Corbeil et al., 1999: Corbeil S, Lapatra SE, Anderson ED, Jones J, Vincent B, Hsu YL, Kurath G. Evaluation of the protective immunogenicity of the N, P, M, NV and G proteins of infectious hematopoietic necrosis virus in rainbow trout oncorhynchus mykiss using DNA vaccines. Diseases of aquatic organisms. 1999; 39(1); 29-36. [PubMed: 11407402].