VIOLIN Logo
VO Banner
Search: for Help
About
Introduction
Statistics
VIOLIN News
Your VIOLIN
Register or Login
Submission
Tutorial
Vaccine & Components
Vaxquery
Vaxgen
VBLAST
Protegen
VirmugenDB
DNAVaxDB
CanVaxKB
Vaxjo
Vaxvec
Vevax
Huvax
Vaccine Mechanisms
Vaximmutordb
Vaxism
Vaxar
Vaccine Literature
VO-SciMiner
Litesearch
Vaxmesh
Vaxlert
Vaccine Design
Vaxign
Community Efforts
Vaccine Ontology
ICoVax 2012
ICoVax 2013
Advisory Committee
Vaccine Society
Vaxperts
VaxPub
VaxCom
VaxLaw
VaxMedia
VaxMeet
VaxFund
VaxCareer
Data Exchange
V-Utilities
VIOLINML
Help & Documents
Publications
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

Vaccine Comparison

Human metapneumovirus G protein mutant vaccine Human metapneumovirus M2-2 mutant vaccine
Vaccine Information Vaccine Information
  • Vaccine Ontology ID: VO_0002976
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: African green monkey
  • G protein gene engineering:
    • Type: Gene mutation
    • Description: This G protein is from Human metapneumovirus (Biacchesi et al., 2005).
    • Detailed Gene Information: Click Here.
  • Immunization Route: intranasal immunization
  • Vaccine Ontology ID: VO_0002977
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: African green monkeys
  • M2-2 gene engineering:
    • Type: Gene mutation
    • Description: This M2-2 mutant is from Human metapneumovirus (Biacchesi et al., 2005).
    • Detailed Gene Information: Click Here.
  • Immunization Route: intranasal immunization
Host Response Host Response

Monkey Response

  • Persistence: A G protein mutant is attenuated in African green monkeys (Biacchesi et al., 2005).
  • Efficacy: A G protein mutant induces significant protection in African green monkeys from challenge with wild type HMPV (Biacchesi et al., 2005).

Monkey Response

  • Persistence: An M2-2 mutant is attenuated in African green monkeys (Biacchesi et al., 2005).
  • Efficacy: An M2-2 mutant induces significant protection in African green monkeys from challenge with wild type HMPV (Biacchesi et al., 2005).
References References
Biacchesi et al., 2005: Biacchesi S, Pham QN, Skiadopoulos MH, Murphy BR, Collins PL, Buchholz UJ. Infection of nonhuman primates with recombinant human metapneumovirus lacking the SH, G, or M2-2 protein categorizes each as a nonessential accessory protein and identifies vaccine candidates. Journal of virology. 2005; 79(19); 12608-12613. [PubMed: 16160190].
Biacchesi et al., 2005: Biacchesi S, Pham QN, Skiadopoulos MH, Murphy BR, Collins PL, Buchholz UJ. Infection of nonhuman primates with recombinant human metapneumovirus lacking the SH, G, or M2-2 protein categorizes each as a nonessential accessory protein and identifies vaccine candidates. Journal of virology. 2005; 79(19); 12608-12613. [PubMed: 16160190].