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Vaccine Detail

Dengue virus DNA vaccine D1ME encoding prM and E
Vaccine Information
  • Vaccine Ontology ID: VO_0004470
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Monkey
  • E gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pVR1012 expressed the dengue-1 pre-membrane (prM) and full-length envelope (E) genes (Raviprakash et al., 2000).
    • Detailed Gene Information: Click Here.
  • prM gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pVR1012 (Vical Inc.) expressed the dengue-1 pre-membrane (prM) and full-length envelope (E) genes (Raviprakash et al., 2000).
    • Detailed Gene Information: Click Here.
  • Vector: pVR1012 (Vical Inc.) (Raviprakash et al., 2000)
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Monkey Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Four of the eight i.m.-inoculated monkeys were protected completely from developing viraemia when challenged 4 months after the last dose with homologous dengue virus. The other four monkeys had reduced viraemia compared with the control immunized monkeys. The i.d. -inoculated monkeys showed no reduction in viraemia when challenged with the virus (Raviprakash et al., 2000).
References
Raviprakash et al., 2000: Raviprakash K, Porter KR, Kochel TJ, Ewing D, Simmons M, Phillips I, Murphy GS, Weiss WR, Hayes CG. Dengue virus type 1 DNA vaccine induces protective immune responses in rhesus macaques. The Journal of general virology. 2000; 81(Pt 7); 1659-1667. [PubMed: 10859370].