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Vaccine Detail

Dengue Virus DNA Vaccine D1ME-VRP
Vaccine Information
  • Vaccine Ontology ID: VO_0004548
  • Type: DNA vaccine
  • Status: Research
  • prM gene engineering:
    • Type: DNA vaccine construction
    • Detailed Gene Information: Click Here.
  • E gene engineering:
    • Type: DNA vaccine construction
    • Detailed Gene Information: Click Here.
  • Vector: D1ME-DNA (Chen et al., 2007)
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Baboon Response

  • Vaccination Protocol: Monkeys were divided into groups DDD, VVV, DDV, and control and immunized with D1ME-DNA or D1ME-VRP as shown in the study design. D1ME-DNA was administered intramuscularly, with 0.5 ml given in each of the two upper arms. D1ME-VRP was delivered intramuscularly, as well (Chen et al., 2007).
  • Vaccine Immune Response Type: VO_0003057
  • Immune Response: After the third dose of vaccine, all animals in the DDD group, VVV group, and DDV group had developed neutralizing antibodies. The dengue virus 1-specific IgG response to all vaccination regimens was predominantly of the IgG1 type, with smaller amounts of IgG2 and no measurable amounts of IgG4 (Chen et al., 2007).
  • Challenge Protocol: Twenty weeks after the final immunization, animals were challenged by subcutaneous injection of 105 PFU of live dengue virus 1 (Western Pacific 74 strain) in a 0.5-ml volume (Chen et al., 2007).
  • Efficacy: All vaccination regimens showed significant protection from viremia compared to that of the unvaccinated control group (Chen et al., 2007).
References
Chen et al., 2007: Chen L, Ewing D, Subramanian H, Block K, Rayner J, Alterson KD, Sedegah M, Hayes C, Porter K, Raviprakash K. A heterologous DNA prime-Venezuelan equine encephalitis virus replicon particle boost dengue vaccine regimen affords complete protection from virus challenge in cynomolgus macaques. Journal of virology. 2007; 81(21); 11634-11639. [PubMed: 17715224].