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Vaccine Detail

Vibrio cholerae hemA mutant vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0002934
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Rabbit
  • hemA gene engineering:
  • Immunization Route: Oral immunization
Host Response

Rabbit Response

  • Persistence: A hemA mutant is highly attenuated in rabbits (Ravichandran et al., 2006).
  • Efficacy: A hemA mutant induces protection in rabbits from challenge with wild type V. cholerae (Ravichandran et al., 2006).
  • Host IgA response
    • Description: VCUSM2 elicited high titer of anti-LPS IgG/IgA antibodies on the fourth week post-vaccination. These titers were comparable to those elicited by the wild type strain and were significantly higher than titers pre-vaccination (Ravichandran et al., 2006).
    • Detailed Gene Information: Click Here.
  • Host IgG Fc fragment response
    • Description: VCUSM2 elicited high titer of anti-LPS IgG/IgA antibodies on the fourth week post-vaccination. These titers were comparable to those elicited by the wild type strain and were significantly higher than titers pre-vaccination (Ravichandran et al., 2006).
    • Detailed Gene Information: Click Here.
References
Ravichandran et al., 2006: Ravichandran M, Ali SA, Rashid NH, Kurunathan S, Yean CY, Ting LC, Bakar AS, Lalitha P, Zainuddin ZF. Construction and evaluation of a O139 Vibrio cholerae vaccine candidate based on a hemA gene mutation. Vaccine. 2006; 24(18); 3750-3761. [PubMed: 16102875].