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Vaccine Detail

Human papillomavirus DNA vaccine VlJns-Ll encoding L1
Vaccine Information
  • Vaccine Ontology ID: VO_0004328
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Rabbit
  • L1 gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector VlJns expressed the major viral capsid protein L1 (Donnelly et al., 1996).
    • Detailed Gene Information: Click Here.
  • Vector: VlJns (Donnelly et al., 1996)
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Rabbit Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Immunization with plasmid DNA encoding L1 elicited conformationally specific neutralizing antibodies and provided immunity against papilloma formation upon challenge with CRPV (Donnelly et al., 1996).
References
Donnelly et al., 1996: Donnelly JJ, Martinez D, Jansen KU, Ellis RW, Montgomery DL, Liu MA. Protection against papillomavirus with a polynucleotide vaccine. The Journal of infectious diseases. 1996; 173(2); 314-320. [PubMed: 8568291].