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Vaccine Detail

rvOka-HN (mumps virus)
Vaccine Information
  • Vaccine Ontology ID: VO_0004709
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • HN gene engineering:
    • Type: Recombinant vector construction
    • Description: A recombinant varicella-zoster virus (VZV) Oka vaccine strain (vOka) that contained the mumps virus (MuV) hemagglutinin-neuraminidase (HN) gene, inserted into the site of the ORF 13 gene (Somboonthum et al., 2007).
    • Detailed Gene Information: Click Here.
  • Preparation: Recombinant varicella-zoster virus (VZV) Oka vaccine strain (vOka) that contained the mumps virus (MuV) hemagglutinin-neuraminidase (HN) gene, inserted into the site of the ORF 13 gene by using the bacterial artificial chromosome (BAC) system in Escherichia coli (Somboonthum et al., 2007).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Guinea pig Response

  • Vaccination Protocol: Immunization of guinea pigs with rvOka-HN-induced VZV- and HN-specific antibodies (Somboonthum et al., 2007)
  • Vaccine Immune Response Type: VO_0003057
  • Efficacy: Interestingly, the induced antibodies had a strong neutralizing activity against virus-cell infections of both MuV and VZV. Therefore, the novel varicella vaccine expressing MuV HN protein is suitable as a polyvalent live attenuated vaccine against VZV and MuV infections (Somboonthum et al., 2007).
References