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Vaccine Detail

rSPV/H3-2A-H1
Vaccine Information
  • Vaccine Ontology ID: VO_0004755
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • Preparation: Recombinant swinepox virus (rSPV/H3-2A-H1) co-expressing hemagglutinin (HA1) of SIV subtypes H1N1 and H3N2 (Xu et al., 2013).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Guinea pig Response

  • Vaccination Protocol: Guinea pigs in groups 1 and 2 were inoculated in all four legs with 0.4 × 107.0 TCID50 of rSPV/H3-2A-H1 in 0.4 ml EMEM. In groups 3 and 4, each guinea pig was inoculated with 0.4 × 107.0 TCID50 wtSPV in 0.4 ml EMEM. In groups 5 and 6, each guinea pig was inoculated with 0.4 ml of EMEM. All inoculations were administered intramuscularly twice at 1 and 21 days post-inoculation (dpi) (Xu et al., 2013).
  • Vaccine Immune Response Type: VO_0003057
  • Challenge Protocol: At 35 dpi, the guinea pigs in groups 1, 3 and 5 were challenged by nasal inoculation with 0.4 × 105.0 TCID50 SIV H1N1, and those in groups 2, 4 and 6 were challenged with 0.4 × 105.0 TCID50 SIV H3N2 (Xu et al., 2013).
  • Efficacy: Complete protection of guinea pigs against SIV H1N1 or H3N2 challenge was observed. No SIV shedding was detected from guinea pigs vaccinated with rSPV/H3-2A-H1 after challenge. Most importantly, the guinea pigs immunized with rSPV/H3-2A-H1 did not show gross and micrographic lung lesions (Xu et al., 2013).
References
Xu et al., 2013: Xu J, Yang D, Huang D, Xu J, Liu S, Lin H, Zhu H, Liu B, Lu C. Protection of guinea pigs by vaccination with a recombinant swinepox virus co-expressing HA1 genes of swine H1N1 and H3N2 influenza viruses. Archives of virology. 2013; 158(3); 629-637. [PubMed: 23135159].