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Vaccine Comparison

Gallid herpesvirus 1 UL0 mutant vaccine Gallid herpesvirus 1 UL23 mutant vaccine Gallid herpesvirus 1 UL47 mutant vaccine
Vaccine Information Vaccine Information Vaccine Information
  • Vaccine Ontology ID: VO_0002966
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Chicken
  • UL0 gene engineering:
    • Type: Gene mutation
    • Description: This UL0 mutant is from Gallid herpesvirus 1 (Veits et al., 2003).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Eye drop
  • Vaccine Ontology ID: VO_0002967
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Chicken
  • UL23 gene engineering:
    • Type: Gene mutation
    • Description: This UL23 mutant is from Gallid herpesvirus 1 (Han et al., 2002).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intraocular immunization
  • Vaccine Ontology ID: VO_0002968
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Chicken
  • UL47 gene engineering:
    • Type: Gene mutation
    • Description: This UL47 mutant is from Gallid herpesvirus 1 (Helferich et al., 2007).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intratracheal immunization
Host Response Host Response Host Response

Chicken Response

  • Persistence: A UL0 mutant is attenuated in chickens (Veits et al., 2003).
  • Efficacy: A UL0 mutant induces significant protection in chickens from challenge with wild type gallid herpesvirus 1 (Veits et al., 2003).

Chicken Response

  • Persistence: A UL23 mutant is attenuated in chickens (Han et al., 2002).
  • Efficacy: A UL23 mutant induces significant protection in chickens from challenge with wild type GHV-1 (Han et al., 2002).

Chicken Response

References References References
Veits et al., 2003: Veits J, L├╝schow D, Kindermann K, Werner O, Teifke JP, Mettenleiter TC, Fuchs W. Deletion of the non-essential UL0 gene of infectious laryngotracheitis (ILT) virus leads to attenuation in chickens, and UL0 mutants expressing influenza virus haemagglutinin (H7) protect against ILT and fowl plague. The Journal of general virology. 2003; 84(Pt 12); 3343-3352. [PubMed: 14645915].
Han et al., 2002: Han MG, Kweon CH, Mo IP, Kim SJ. Pathogenicity and vaccine efficacy of a thymidine kinase gene deleted infectious laryngotracheitis virus expressing the green fluorescent protein gene. Archives of virology. 2002; 147(5); 1017-1031. [PubMed: 12021870].
Helferich et al., 2007: Helferich D, Veits J, Teifke JP, Mettenleiter TC, Fuchs W. The UL47 gene of avian infectious laryngotracheitis virus is not essential for in vitro replication but is relevant for virulence in chickens. The Journal of general virology. 2007; 88(Pt 3); 732-742. [PubMed: 17325345].