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Vaccine Comparison

Ac-CMV-S1 (infectious bronchitis virus) IBV DNA vaccine pVAX1-16S1/M/N IBV DNA vaccine pVAX1-N Infectious Bronchitis Virus DNA Vaccine encoding S1, N, and M
Vaccine Information Vaccine Information Vaccine Information Vaccine Information
  • Vaccine Ontology ID: VO_0004753
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • S1 gene engineering:
    • Type: Recombinant vector construction
    • Description: The BacMam virus Ac-CMV-S1, which expressed the S1 glycoprotein of IBV-M41 (Zhang et al., 2014).
    • Detailed Gene Information: Click Here.
  • Preparation: BV-Dual-S1 expresses the S1 glycoprotein of IBV-M41 on the baculovirus envelope, and is capable of expressing it in mammalian cells (Zhang et al., 2014).
  • Immunization Route: Intramuscular injection (i.m.)
  • Vaccine Ontology ID: VO_0004535
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Chickens
  • Antigen: S1, N, and M proteins of the virulent IBVSX16 strain (Yan et al., 2013)
  • M membrane protein gene engineering:
    • Type: DNA vaccine construction
    • Detailed Gene Information: Click Here.
  • N protein gene engineering:
    • Type: DNA vaccine construction
    • Detailed Gene Information: Click Here.
  • S1 gene engineering:
    • Type: DNA vaccine construction
    • Detailed Gene Information: Click Here.
  • Vector: pVAX1 prime, inactivated IBV vaccine boost (Yan et al., 2013)
  • Immunization Route: Intramuscular injection (i.m.)
  • Vaccine Ontology ID: VO_0004581
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Chickens
  • N protein gene engineering:
    • Type: DNA vaccine construction
    • Detailed Gene Information: Click Here.
  • Vector: pVAX1 prime, inactivated IBV vaccine boost (Guo et al., 2010)
  • Immunization Route: Intramuscular injection (i.m.)
  • Vaccine Ontology ID: VO_0004584
  • Type: DNA vaccine
  • Status: Research
  • N protein gene engineering:
    • Type: DNA vaccine construction
    • Detailed Gene Information: Click Here.
  • S1 gene engineering:
    • Type: DNA vaccine construction
    • Detailed Gene Information: Click Here.
  • M membrane protein gene engineering:
    • Type: DNA vaccine construction
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
Host Response Host Response Host Response Host Response

Chicken Response

  • Vaccination Protocol: The chickens were immunized with BV-Dual-S1 or an inactivated vaccine (Zhang et al., 2014).
  • Vaccine Immune Response Type: VO_0003057
  • Challenge Protocol: The immunized chickens were challenged with a virulent IBV-M41 (Zhang et al., 2014).
  • Efficacy: A significant difference was not observed for protection rates between chickens immunized with BV-Dual-S1 (83%) or inactivated vaccine (89%) following challenge with virulent IBV-M41. Our findings show that the protective efficacy of BV-Dual-S1 could be significantly enhanced by baculovirus display technology (Zhang et al., 2014).

Chicken Response

  • Vaccination Protocol: Chickens were immunized with the multivalent DNA vaccine twice and then boosted with an inactivated vaccine once (Yan et al., 2013).
  • Immune Response: Antibody titers of the chickens immunized with pVAX1-16S1/M/N were much higher than those of the monovalent groups (p < 0.01) (Yan et al., 2013).
  • Efficacy: A protective rate up to 90% was observed in the pVAX1-16S1/M/N group (Yan et al., 2013).

Chicken Response

  • Vaccine Immune Response Type: VO_0003057
  • Efficacy: Priming with a DNA vaccine encoding nucleocapsid protein (pVAX1-N) and boosting with the inactivated IBV vaccine provided up to 86.7% rate of immune protection, compared to the lack of protection seen in the PBS-immunized group, where the death rate was 66.7% (Guo et al., 2010).

Chicken Response

  • Vaccination Protocol: The seven day old SPF chickens were randomly divided into six groups with 20 chickens per group. Groups 1–3 received 100 micro-g of pVAX1-S1, PVAX1-M, or pVAX1-N,
    respectively; Group 4 received 100 micro-g combined DNA vaccine containing 33 micro-g of each of the three antigen plasmids; Groups 5–6 received 100 micro-g empty pVAX1 and 0.5 ml PBS. All the chickens were immunized intramuscularly with the vaccines at seven days of age (Yang et al., 2009).
  • Vaccine Immune Response Type: VO_0003057
  • Immune Response: Anti-IBV antibody levels were detected in chickens immunized with either pVAX1-S1, pVAX1-M, pVAX1-N or the three constructs in combination. In fact, a higher antibody titer level was observed in chickens immunized with the three expression constructs in combination compared with the individual constructs, suggesting a greater potency for inducing antibody response (Yang et al., 2009).
  • Challenge Protocol: All chickens were challenged with 100EID50 of the IBV SAIBk strain in 0.1 ml by a nasal-ocular route at 21 days after the boost immunization (Yang et al., 2009).
  • Efficacy: Immunization with the multivalent DNA vaccine provided up to 85% immune protection in the vaccinated chickens (Yang et al., 2009).
References References References References
Zhang et al., 2014: Zhang J, Chen XW, Tong TZ, Ye Y, Liao M, Fan HY. BacMam virus-based surface display of the infectious bronchitis virus (IBV) S1 glycoprotein confers strong protection against virulent IBV challenge in chickens. Vaccine. 2014; 32(6); 664-670. [PubMed: 24342247].
Yan et al., 2013: Yan F, Zhao Y, Hu Y, Qiu J, Lei W, Ji W, Li X, Wu Q, Shi X, Li Z. Protection of chickens against infectious bronchitis virus with a multivalent DNA vaccine and boosting with an inactivated vaccine. Journal of veterinary science. 2013; 14(1); 53-60. [PubMed: 23388447].
Guo et al., 2010: Guo Z, Wang H, Yang T, Wang X, Lu D, Li Y, Zhang Y. Priming with a DNA vaccine and boosting with an inactivated vaccine enhance the immune response against infectious bronchitis virus. Journal of virological methods. 2010; 167(1); 84-89. [PubMed: 20307574].
Yang et al., 2009: Yang T, Wang HN, Wang X, Tang JN, Gao R, Li J, Guo ZC, Li YL. Multivalent DNA vaccine enhanced protection efficacy against infectious bronchitis virus in chickens. The Journal of veterinary medical science / the Japanese Society of Veterinary Science. 2009; 71(12); 1585-1590. [PubMed: 20046025].