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Vaccine Detail

Salmonella IroN Protein Vaccine
Vaccine Information
  • Vaccine Name: Salmonella IroN Protein Vaccine
  • Target Pathogen: Salmonella spp.
  • Target Disease: Salmonellosis
  • Vaccine Ontology ID: VO_0004184
  • Type: Subunit vaccine
  • Status: Research
  • IroN gene engineering:
    • Type: Recombinant protein preparation
    • Description:
    • Detailed Gene Information: Click Here.
  • Adjuvant: incomplete Freunds adjuvant
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Chicken Response

  • Host Strain: white leghorn
  • Vaccination Protocol: Ten 30-day-old specific-pathogen-free (SPF) white leghorn chickens were immunized intramuscularly with 0.5 ml of purified IroN (0.05 mg/ml), homogenized with Freund's incomplete adjuvant, and 10 control chickens were immunized intramuscularly with PBS homogenized with Freund's incomplete adjuvant. The immunized chickens were given an intramuscular booster injection 3 wk after the first immunization (Kaneshige et al., 2009).
  • Challenge Protocol: Three weeks after the second injection, the immunized chickens and controls were challenged intravenously with 108 CFU of Salmonella Enteritidis (Kaneshige et al., 2009).
  • Efficacy: The mortality rate of immunized chickens was 10%, while that of control chickens was 80% (Kaneshige et al., 2009).
References
Kaneshige et al., 2009: Kaneshige T, Yaguchi K, Ohgitani T. Siderophore receptor IroN is an important protective antigen against Salmonella infection in chickens. Avian diseases. 2009; 53(4); 563-567. [PubMed: 20095157].