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Vaccine Detail

S. agalactiae BPS Protein Vaccine
Vaccine Information
  • Vaccine Name: S. agalactiae BPS Protein Vaccine
  • Target Pathogen: Streptococcus agalactiae
  • Target Disease: Group B streptococcus (GBS) infection
  • Vaccine Ontology ID: VO_0004050
  • Type: Subunit vaccine
  • Status: Research
  • Antigen: Recombinant BPS
  • sar5 gene engineering:
    • Type: Recombinant protein preparation
    • Description:
    • Detailed Gene Information: Click Here.
  • Adjuvant: aluminum phosphate vaccine adjuvant
  • Immunization Route: subcutaneous injection
Host Response

Mouse Response

  • Host Strain: BALB/c
  • Vaccination Protocol: Four-week-old female BALB/c (H-2d) mice were immunized with recombinant BPS protein on days 1, 3, 6, and 27 (30 μg/dose) by the subcutaneous route with aluminum phosphate as the adjuvant (Erdogan et al., 2002).
  • Challenge Protocol: Groups of immunized and control animals were challenged on day 37 with an inoculum of the streptococcal strain Compton R corresponding to the 80% lethal dose (LD80; 5 × 108 bacteria/ml) in nonimmunized mice, and mortality was recorded daily (Erdogan et al., 2002).
  • Efficacy: When the immunized animals were challenged with strain Compton R, approximately 88% of the vaccinated animals survived whereas mice in the control group were not protected (78% lethality) (Erdogan et al., 2002).
References
Erdogan et al., 2002: Erdogan S, Fagan PK, Talay SR, Rohde M, Ferrieri P, Flores AE, Guzmán CA, Walker MJ, Chhatwal GS. Molecular analysis of group B protective surface protein, a new cell surface protective antigen of group B streptococci. Infection and immunity. 2002; 70(2); 803-811. [PubMed: 11796614].