• Vaccine Name: S. agalactiae BPS Protein Vaccine
• Target Pathogen: Streptococcus agalactiae
• Target Disease: Group B streptococcus (GBS) infection
• Vaccine Ontology ID: VO_0004050
• Type: Subunit vaccine
• Status: Research
• Antigen: Recombinant BPS
• sar5 gene engineering:
  • Type: Recombinant protein preparation
  • Description:
  • Detailed Gene Information: Click Here.
• Adjuvant:
  • Adjuvant name:
  • VO adjuvant ID: VO_0000128
  • Description: Aluminum phosphate (Adju-Phos; Axell Accurate Chemical & Scientific Corp.) (Erdogan et al., 2002).
• Immunization Route: subcutaneous injection

Mouse Response

• Host Strain: BALB/c
• Vaccination Protocol: Four-week-old female BALB/c (H-2d) mice were immunized with recombinant BPS protein on days 1, 3, 6, and 27 (30 μg/dose) by the subcutaneous route with aluminum phosphate as the adjuvant (Erdogan et al., 2002).
• Challenge Protocol: Groups of immunized and control animals were challenged on day 37 with an inoculum of the streptococcal strain Compton R corresponding to the 80% lethal dose (LD80; 5 × 10^8 bacteria/ml) in nonimmunized mice, and mortality was recorded daily (Erdogan et al., 2002).
• Efficacy: When the immunized animals were challenged with strain Compton R, approximately 88% of the vaccinated animals survived whereas mice in the control group were not protected (78% lethality) (Erdogan et al., 2002).