• Vaccine Name: P. falciparum CS expressed in irradiated P. berghei as Vaccine
• Target Pathogen: Plasmodium spp.
• Target Disease: Malaria
• Vaccine Ontology ID: VO_0004794
• Type: Recombinant vector vaccine
• Status: Research
• Antigen: CSP from P. falciparum
• CS from P. falciparum gene engineering:
  • Type: Recombinant vector construction
  • Description: P. berghei ANKA cloned lines were transfected with the P. falciparum CSP gene (Grüner et al., 2007).
  • Detailed Gene Information: Click Here.
• Immunization Route: non-specified injection

Mouse Response

• Host Strain: BALB/cJ
• Vaccination Protocol: In order to induce sterile immunity in all the animals, BALB/cJ mice were immunized with 12,000 rad-irradiated P. berghei sporozoites as follows: one dose of 75,000 sporozoites followed by two booster doses of 25,00 of P. berghei sporozoites on days 15 and 21. In [BALB/c×C57BL/6] F1 mice immunisation was made with 3 injections of 10,000 P. berghei irradiated sporozoites at days 0, 15 and 21 (Grüner et al., 2007).
• Challenge Protocol: Control mice and mice immunized with irradiated sporozoites (transfected with P. falciparum CS) were challenged intravenously with 5,000 P. berghei or P. berghei [PfCS] sporozoites (Grüner et al., 2007).
• Efficacy: Mice immunized with irradiated sporozoites were protected from challenge (Grüner et al., 2007).