• Vaccine Name: J5dLPS/OMP
• Target Pathogen: Francisella tularensis
• Target Disease: Tularemia
• Vaccine Ontology ID: VO_0004201
• Type: Subunit vaccine
• Status: Research
• Antigen: Detoxified, O-polysaccharide side chain-deficient, lipopolysaccharide non-covalently complexed with the outer membrane protein of N. meningitidis group B (Gregory et al., 2010).
• Adjuvant:
  • Adjuvant name:
  • VO adjuvant ID: VO_0001237
• Immunization Route: intranasal immunization

Mouse Response

• Host Strain: BALB/c
• Vaccination Protocol: Ten, 6- to 8-week-old mice were inoculated i.n. with 1 μg J5dLPS/OMP vaccine at 0, 2, and 4 weeks. Unmethylated cytidine-phosphate-guanosine (CpG) containing oligodinucleotide (ODN 10104; Coley Pharmaceutical Group, Wellesley, MA) was administered i.n. (25 μg/mouse) one hour prior to each vaccination. Control groups received CpG ODN only (Gregory et al., 2010).
• Challenge Protocol: Vaccinated mice were challenged i.t. with F. tularensis SchuS4 on days 35 - 42 post-vaccination (Gregory et al., 2010).
• Efficacy: Mice vaccinated with J5dLPS/OMP and CpG ODN resisted infection by type A F. tularensis. Sixty-five percent of vaccinated animals survived challenge i.t. with 10 LD50 F. tularensis SchuS4 (Gregory et al., 2010).