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Vaccine Detail

Broilact Chick Salmonella vaccine
Vaccine Information
  • Vaccine Name: Broilact Chick Salmonella vaccine
  • Target Pathogen: Salmonella spp.
  • Target Disease: Salmonellosis
  • Tradename: Broilact
  • Vaccine Ontology ID: VO_0004140
  • Type: Live, attenuated vaccine
  • Antigen: Broilact is a preparation of the complex mixture of bacteria that inhabit the gut of the healthy adult fowl. The Broilact bacteria are able to live normally in the gut and minimise its colonisation by undesirable and harmful bacteria (Game Bird Health - Broilact).
  • Preparation: Broilact consists of obligately and facultatively anaerobic chicken intestinal bacteria. (Schneitz and Renney, 2003)
  • Description: As a competitive exclusion product, Broilact substantially reduces colonization of the intestine of a host animal by Salmonella infantis (Schneitz and Renney, 2003).
Host Response

Copper Pheasant Response

  • Host Strain: Copper Pheasant
  • Vaccination Protocol: Groups of 10 chicks were given 1.0 mg in a dose volume of 0.3 ml of Broilact through gavage (Schneitz and Renney, 2003).
  • Challenge Protocol: The challenge was created with a 24-hr brain-heart infusion broth culture of a nalidixic-acid-resistant derivative of Salmonella infantis. All birds were challenged 24 hours after initial dosage. Birds in trial 1 received 4.4 x 103 cfu each, while the birds in trials 2 and 3 received 4.3 x 103 cfu each (Schneitz and Renney, 2003).
  • Efficacy: Significant protection was induced by Broilact in all three trials (Schneitz and Renney, 2003).

Chicken Response

  • Host Strain: Isa Brown
  • Vaccination Protocol: Two trials of 20 chicks were inoculated through gavage at 20 times the normal dose of Broilact, 0.25 ml (Salvat et al., 1992).
  • Challenge Protocol: The challenge was given to the chicks through gavage using 0.1 ml of an 18-h diluted cuture. The first trial of chicks recieved 7.0 x 104 cfu per chick, while the second trial of chicks was inoculated with 5.7 x 103 cfu per chick (Salvat et al., 1992).
  • Efficacy: The protection factor (PF) was above 6 in the first trial and about 2.6 in the second trial at day 3. Protection at day 7 was extremely high (PF over 36 for trial 1 and P over 45 for trial 2) (Salvat et al., 1992).
References
Game Bird Health - Broilact: Game Bird Health - Broilact [http://www.gamebirdhealth.co.uk/broilact.htm]
Salvat et al., 1992: Salvat G, Lalande F, Humbert F, Lahellec C. Use of a competitive exclusion product (Broilact) to prevent Salmonella colonization of newly hatched chicks. International journal of food microbiology. 1992; 15(3-4); 307-311. [PubMed: 1419536 ].
Schneitz and Renney, 2003: Schneitz C, Renney DJ. Effect of a commerical competitive exclusion product on the colonization of Salmonella infantis in day-old pheasant chicks. Avian diseases. 2003; 47(4); 1448-1451. [PubMed: 14708995 ].