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Vaccine Detail
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rHA with IL-2 adjuvant |
| Vaccine Information |
- Vaccine Name: rHA with IL-2 adjuvant
- Target Pathogen: Influenza virus
- Target Disease: Influenza (flu)
- Vaccine Ontology ID: VO_0004236
- Type: Subunit vaccine
- Status: Research
- Antigen: Baculovirus-expressed recombinant influenza virus hemagglutinin (rHA) derived from influenza virus A/New Caledonia/20/1999 (Kayamuro et al., 2010).
- Adjuvant:
- Immunization Route: intranasal immunization
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| Host Response |
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Mouse Response
- Vaccination Protocol: Mice were immunized intranasally with rHA alone (1 µg/mouse), rHA (1 µg/mouse) plus CT (1 µg/mouse), or rHA (1 µg/mouse) plus one of the IL cytokines (0.1 µg, 0.3 µg, or 1.0 µg/mouse) on days 0 and 28 (Kayamuro et al., 2010).
- Immune Response: Consistent with the rHA-specific IgG responses, intranasal immunization with rHA plus IL-2 produced a greater rHA-specific IgG1 subclass response than immunization with rHA alone but a similar IgG2a response to that with rHA alone (Kayamuro et al., 2010).
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| References |
Kayamuro et al., 2010: Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. Journal of virology. 2010; 84(24); 12703-12712. [PubMed: 20881038].
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