• Vaccine Name: Inactivated split Mem 71 Virus with SPT adjuvant
• Target Pathogen: Influenza virus
• Target Disease: Influenza (flu)
• Vaccine Ontology ID: VO_0004244
• Type: Inactivated or "killed" vaccine
• Status: Research
• Antigen: Inactivated Mem 71virus (A/Memphis/l/71 x A/Bellamy/42 (H3N1) recombinant) (Deliyannis et al., 1998).
• Adjuvant:
  • Adjuvant name:
  • VO adjuvant ID: VO_0001315
• Immunization Route: subcutaneous injection

Mouse Response

• Host Strain: BALB/c
• Vaccination Protocol: Mice were immunized subcutaneously on day 0 with 0.1 ml of vaccine containing various doses of split Mem 71 virus with or without adjuvant (Deliyannis et al., 1998).
• Challenge Protocol: MIce were challenged intranasally with 10^4.5 plaque forming units (p.f.u.) of live Mem 71 influenza virus (Deliyannis et al., 1998).
• Efficacy: Protection from subsequent influenza infection was assessed by examining the ability of vaccinated mice to clear a challenge dose of virus from their lungs by 3 days postinfection. Mice immunized with virus in SPT adjuvant had greater levels of viral clearance than in mice immunized without adjuvant (Deliyannis et al., 1998).