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Vaccine Detail

Anthrax vaccine adsorbed with Squalene adjuvant
Vaccine Information
  • Vaccine Name: Anthrax vaccine adsorbed with Squalene adjuvant
  • Target Pathogen: Bacillus anthracis
  • Target Disease: Anthrax
  • Vaccine Ontology ID: VO_0004246
  • Type: Toxoid vaccine
  • Status: Research
  • Adjuvant: squalene
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Host Strain: Hartley
  • Vaccination Protocol: Mice were immunized intramuscularly (i.m.) at 0 and 4 weeks (Ivins et al., 1995).
  • Challenge Protocol: Animals were challenged at 10 weeks post vaccination with an aerosol of spores of B. anthracis Ames strain (Ivins et al., 1995).
  • Efficacy: The vaccine adjuvanted with SLT (squalene) was more protective than the vaccine without the squalene adjuvant (Ivins et al., 1995).
References
Ivins et al., 1995: Ivins B, Fellows P, Pitt L, Estep J, Farchaus J, Friedlander A, Gibbs P. Experimental anthrax vaccines: efficacy of adjuvants combined with protective antigen against an aerosol Bacillus anthracis spore challenge in guinea pigs. Vaccine. 1995; 13(18); 1779-1784. [PubMed: 8701593].