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Vaccine Detail
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Anthrax vaccine adsorbed with Squalene adjuvant |
| Vaccine Information |
- Vaccine Name: Anthrax vaccine adsorbed with Squalene adjuvant
- Target Pathogen: Bacillus anthracis
- Target Disease: Anthrax
- Vaccine Ontology ID: VO_0004246
- Type: Toxoid vaccine
- Status: Research
- Adjuvant:
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Host Strain: Hartley
- Vaccination Protocol: Mice were immunized intramuscularly (i.m.) at 0 and 4 weeks (Ivins et al., 1995).
- Challenge Protocol: Animals were challenged at 10 weeks post vaccination with an aerosol of spores of B. anthracis Ames strain (Ivins et al., 1995).
- Efficacy: The vaccine adjuvanted with SLT (squalene) was more protective than the vaccine without the squalene adjuvant (Ivins et al., 1995).
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| References |
Ivins et al., 1995: Ivins B, Fellows P, Pitt L, Estep J, Farchaus J, Friedlander A, Gibbs P. Experimental anthrax vaccines: efficacy of adjuvants combined with protective antigen against an aerosol Bacillus anthracis spore challenge in guinea pigs. Vaccine. 1995; 13(18); 1779-1784. [PubMed: 8701593].
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