• Vaccine Name: Inactivated H1N1(2009) Vaccine with AF03 adjuvant
• Target Pathogen: Influenza virus
• Target Disease: Influenza (flu)
• Vaccine Ontology ID: VO_0004253
• Type: Inactivated or "killed" vaccine
• Status: Research
• Adjuvant:
  • Adjuvant name:
  • VO adjuvant ID: VO_0001330
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Host Strain: BALB/c
• Vaccination Protocol: Mice were primed with injection of one of two formulations of Vaxigrip. Forty days post-TIV priming (designated as Day 0), vaccinated mice were divided into four subgroups of 10 animals each and were re-vaccinated with a monovalent inactivated pandemic H1N1 (2009) vaccine prepared using the NYMC X-179A (A/California/07/2009 H1N1) reassortant strain. Four formulations were evaluated: 3 μg HA or 0.3 μg HA, as 1/10th and 1/100th of the highest immunization doses used in clinical trials; each HA dose was formulated with or without an oil-in-water emulsion adjuvant (AF03; sanofi pasteur, Lyon, France) (Caillet et al., 2010).
• Immune Response: The immunogenicity results of these studies with AF03-adjuvanted H1N1 vaccine in mice are consistent with clinical studies of H5N1 influenza vaccines, in which HI responses were significantly increased by the addition of this emulsion-based adjuvant (Caillet et al., 2010).