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Vaccine Detail

pneumococcal polysaccharide conjugate vaccine serotype 1 (PNC-1)
Vaccine Information
  • Vaccine Name: pneumococcal polysaccharide conjugate vaccine serotype 1 (PNC-1)
  • Target Pathogen: Streptococcus pneumoniae
  • Target Disease: Pneumonia
  • Vaccine Ontology ID: VO_0004265
  • Type: Conjugate vaccine
  • Status: Research
  • Adjuvant: LTK72 vaccine adjuvant
  • Immunization Route: intranasal immunization
Host Response

Mouse Response

  • Host Strain: NMRI
  • Vaccination Protocol: Mice were immunized i.n. with 0.5 or 2.0 μg of PNC-1 alone or mixed with either LT-K63 or LT-R72 (Jakobsen et al., 1999).
  • Immune Response: Administration of PNC-1 i.n. with either LT-K63 or LT-R72 elicited significantly higher antibody responses than the s.c. route for both 0.5- and 2.0-μg doses of PNC-1 in saline (Jakobsen et al., 1999).
  • Challenge Protocol: Mice were challenged with 50 μl of pneumococcal suspension i.n. and were allowed to aspirate it into the lungs for 10 min (Jakobsen et al., 1999).
  • Efficacy: Immunization i.n. with PNC-1 and LT-K63 or LT-R72 conferred 100% clearance of lung infection caused by serotype 1 pneumococci (Jakobsen et al., 1999).
References
Jakobsen et al., 1999: Jakobsen H, Schulz D, Pizza M, Rappuoli R, Jónsdóttir I. Intranasal immunization with pneumococcal polysaccharide conjugate vaccines with nontoxic mutants of Escherichia coli heat-labile enterotoxins as adjuvants protects mice against invasive pneumococcal infections. Infection and immunity. 1999; 67(11); 5892-5897. [PubMed: 10531245].