• Vaccine Name: B. anthracis PA protein Vaccine with TMDP
• Target Pathogen: Bacillus anthracis
• Target Disease: Anthrax
• Vaccine Ontology ID: VO_0004270
• Type: Subunit vaccine
• Status: Research
• Antigen: B. anthracis PA protein (Ivins et al., 1992).
• Adjuvant:
  • Adjuvant name:
  • VO adjuvant ID: VO_0001351
• Immunization Route: Intramuscular injection (i.m.)

Guinea pig Response

• Host Strain: Hartley
• Vaccination Protocol: Several adjuvant preparations combined with PA were compared with each other and with MDPH-PA with respect to protection and elicitation of anti-PA antibody. In the first experiment, guinea pigs received one or more injections of each preparation (Ivins et al., 1992).
• Challenge Protocol: Guinea pigs were challenged i.m. 10 weeks after the first immunization with 7,300 (73 LD50) of B. anthracis Ames spores (Ivins et al., 1992).
• Efficacy: 12/18 guinea pigs survived challenge after immunization with 1 dose of PA + TMDP and 13/20 survived after 2 doses of PA + TMDP (Ivins et al., 1992).