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Vaccine Detail

Bacillus anthracis mntA deletion mutant vaccine
Vaccine Information
  • Vaccine Name: Bacillus anthracis mntA deletion mutant vaccine
  • Target Pathogen: Bacillus anthracis
  • Target Disease: Anthrax
  • Vaccine Ontology ID: VO_0002775
  • Type: Live, attenuated vaccine
  • Status: Licensed
  • mntA gene engineering:
    • Type: Gene mutation
    • Description:
    • Detailed Gene Information: Click Here.
  • Preparation: An mntA deletion, generated by allelic replacement resulted in complete loss of MntA expression (Gat et al., 2005).
  • Immunization Route: Other
Host Response

Guinea pig Response

  • Persistence: The mntA mutant resulted in severe attenuation; a 10(4)-fold drop in LD(50) in a guinea pig model (Gat et al., 2005).
  • Efficacy: All the guinea pigs were challenged with 60 LD50 of the virulent Vollum strain. All guinea pigs survived this challenge and exhibited antibody titers 103−105 of either anti-PA or anti-LF (Gat et al., 2005).
References
Gat et al., 2005: Gat O, Mendelson I, Chitlaru T, Ariel N, Altboum Z, Levy H, Weiss S, Grosfeld H, Cohen S, Shafferman A. The solute-binding component of a putative Mn(II) ABC transporter (MntA) is a novel Bacillus anthracis virulence determinant. Molecular microbiology. 2005; 58(2); 533-551. [PubMed: 16194238].