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Vaccine Detail

Yersinia pestis guaBA mutant vaccine
Vaccine Information
  • Vaccine Name: Yersinia pestis guaBA mutant vaccine
  • Target Pathogen: Yersinia pestis
  • Target Disease: Plague
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • guaA gene engineering:
    • Type: Gene mutation
    • Description: This guaBA operon is from Yersinia pestis (Oyston et al., 2010).
    • Detailed Gene Information: Click Here.
  • guaB gene engineering:
    • Type: Gene mutation
    • Description: This guaBA operon is from Yersinia pestis (Oyston et al., 2010).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intravenous injection (i.v.)
Host Response

Mouse Response

  • Persistence: A guaBA mutant is attenuated in mice (Oyston et al., 2010).
  • Efficacy: A guaBA mutant induced significant protection from challenge with wild type Yersinia pestis in mice (Oyston et al., 2010).
References
Oyston et al., 2010: Oyston PC, Mellado-Sanchez G, Pasetti MF, Nataro JP, Titball RW, Atkins HS. A Yersinia pestis guaBA mutant is attenuated in virulence and provides protection against plague in a mouse model of infection. Microbial pathogenesis. 2010; 48(5); 191-195. [PubMed: 20096773].