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Vaccine Detail

Yersinia pestis IpxM mutant vaccine
Vaccine Information
  • Vaccine Name: Yersinia pestis IpxM mutant vaccine
  • Target Pathogen: Yersinia pestis
  • Target Disease: Plague
  • Vaccine Ontology ID: VO_0002941
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse, guinea pig
  • IpxM gene engineering:
    • Type: Gene mutation
    • Description: This IpxM mutant is from Yersinia pestis CO92 (Feodorova et al., 2007).
    • Detailed Gene Information: Click Here.
  • Immunization Route: subcutaneous injection
Host Response

Guinea pig Response

  • Persistence: An IpxM mutant is attenuated in guinea pigs (Feodorova et al., 2007).
  • Efficacy: An IpxM mutant conferred significant protection from challenge with wild type Y. pestis in guinea pigs (Feodorova et al., 2007).

Mouse Response

  • Persistence: An IpxM mutant is attenuated in both inbred and outbred mice (Feodorova et al., 2007).
  • Efficacy: An IpxM mutant conferred modest protection from challenge with wild type Y. pestis in Balb/c mice and significant protection from challenge in outbred mice (Feodorova et al., 2007).
References
Feodorova et al., 2007: Feodorova VA, Pan'kina LN, Savostina EP, Sayapina LV, Motin VL, Dentovskaya SV, Shaikhutdinova RZ, Ivanov SA, Lindner B, Kondakova AN, Bystrova OV, Kocharova NA, Senchenkova SN, Holst O, Pier GB, Knirel YA, Anisimov AP. A Yersinia pestis lpxM-mutant live vaccine induces enhanced immunity against bubonic plague in mice and guinea pigs. Vaccine. 2007; 25(44); 7620-7628. [PubMed: 17913308].