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Vaccine Detail

Yersinia pestis smpB/ssrA mutant vaccine
Vaccine Information
  • Vaccine Name: Yersinia pestis smpB/ssrA mutant vaccine
  • Target Pathogen: Yersinia pestis
  • Target Disease: Plague
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • smpB gene engineering:
    • Type: Gene mutation
    • Description: This smpB/ssrA mutant is from Yersinia pestis (Okan et al., 2010).
    • Detailed Gene Information: Click Here.
  • ssrA gene engineering:
    • Type: Gene mutation
    • Description: This smpB/ssrA mutant is from Yersinia pestis (Okan et al., 2010).
    • Detailed Gene Information: Click Here.
  • Immunization Route: intranasal immunization
Host Response

Mouse Response

  • Persistence: An smpB/ssrA mutant is attenuated in mice (Okan et al., 2010).
  • Efficacy: An smpB/ssrA mutant induces significant protection from challenge with wild type Y. pestis in mice (Okan et al., 2010).
References
Okan et al., 2010: Okan NA, Mena P, Benach JL, Bliska JB, Karzai AW. The smpB-ssrA mutant of Yersinia pestis functions as a live attenuated vaccine to protect mice against pulmonary plague infection. Infection and immunity. 2010; 78(3); 1284-1293. [PubMed: 20065026].