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Vaccine Detail

Yersinia pestis yopH mutant vaccine
Vaccine Information
  • Vaccine Name: Yersinia pestis yopH mutant vaccine
  • Target Pathogen: Yersinia pestis
  • Target Disease: Plague
  • Vaccine Ontology ID: VO_0002946
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • YopH from Y. pestis strain: CO92, biovar: Orientalis gene engineering:
    • Type: Gene mutation
    • Description: This yopH mutant is from Yersinia pestis CO92 (Bubeck and Dube, 2007).
    • Detailed Gene Information: Click Here.
  • Immunization Route: intranasal immunization
Host Response

Mouse Response

  • Persistence: A yopH mutant is highly attenuated in mice (Bubeck and Dube, 2007).
  • Efficacy: A yopH mutant induced significant protection from challenge with wild type Y. pestis in mice (Bubeck and Dube, 2007).
References
Bubeck and Dube, 2007: Bubeck SS, Dube PH. Yersinia pestis CO92 delta yopH is a potent live, attenuated plague vaccine. Clinical and vaccine immunology : CVI. 2007; 14(9); 1235-1238. [PubMed: 17652523].