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Vaccine Detail

Yersinia enterocolitica sodA mutant vaccine
Vaccine Information
  • Vaccine Name: Yersinia enterocolitica sodA mutant vaccine
  • Target Pathogen: Yersinia enterocolitica
  • Target Disease: Yersiniosis
  • Vaccine Ontology ID: VO_0002938
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • sodA gene engineering:
    • Type: Gene mutation
    • Description: This sodA mutant is from Yersinia enterocolitica (Igwe et al., 1999).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Oral immunization
Host Response

Mouse Response

  • Persistence: A sodA mutant is attenuated in mice (Igwe et al., 1999).
  • Efficacy: A single dose of a sodA mutant provided protection in mice from challenge with wild type Y. enterocolitica (Igwe et al., 1999).
  • Host Ifng (Interferon gamma) response
    • Description: Restimulated T cells from mice immunized with the mutant strains produced significant quantities of IFN-γ by day 8 after oral immunization compared to the control group of nonrestimulated T cells. However, the amounts of IFN-γ produced by T cells from mice immunized with the mutant strains were lower than those of mice immunized with the wild-type Y. enterocolitica strain (Igwe et al., 1999).
    • Detailed Gene Information: Click Here.
  • Host IgG response
    • Description: Mice immunized with a sodA mutant elicited high titers of serum IgG antibodies. On day 23, WA-314 sodA elicited a 17-fold-higher titer of Yersinia-specific serum IgG antibody than WA irp1 (an irp1 mutant). Mice immunized with WA-314 sodA elicited a 10-fold-higher titer of serum IgG antibody than those given WA(pYVO8-A-2) (a YadA mutant) 90 days after the immunization. IgG levels from days 7 to 90 post-immunization were significantly greater than control serum obtained pre-immunization (Igwe et al., 1999).
    • Detailed Gene Information: Click Here.
References
Igwe et al., 1999: Igwe EI, Rüssmann H, Roggenkamp A, Noll A, Autenrieth IB, Heesemann J. Rational live oral carrier vaccine design by mutating virulence-associated genes of Yersinia enterocolitica. Infection and immunity. 1999; 67(10); 5500-5507. [PubMed: 10496939].