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Vaccine Detail

West Nile virus C protein mutant vaccine
Vaccine Information
  • Vaccine Name: West Nile virus C protein mutant vaccine
  • Target Pathogen: West Nile virus
  • Target Disease: West Nile fever
  • Vaccine Ontology ID: VO_0002998
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • C protein gene engineering:
    • Type: Gene mutation
    • Description: This C protein is from West Nile virus (Schlick et al., 2010).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intraperitoneal injection (i.p.)
Host Response

Mouse Response

  • Persistence: A C protein mutant is attenuated in mice (Schlick et al., 2010).
  • Efficacy: A C protein mutant protects mice from challenge with wild type West Nile virus (Schlick et al., 2010).
  • Host IgG response
    • Description: WNV specific IgG titers were also determined 4 weeks post-challenge. Titers had generally increased to values of 104–105, with the more pronounced increases observed in mice that had been immunized with lower doses of vaccine strains. All animals inoculated with any of the virus mutants seroconverted, whereas serum samples of animals that had received medium alone showed no WNV specific antibody response. A statistically significant increase in IgG over control mice was observed (Schlick et al., 2010).
    • Detailed Gene Information: Click Here.
References
Schlick et al., 2010: Schlick P, Kofler RM, Schittl B, Taucher C, Nagy E, Meinke A, Mandl CW. Characterization of West Nile virus live vaccine candidates attenuated by capsid deletion mutations. Vaccine. 2010; 28(36); 5903-5909. [PubMed: 20600500].